Immunopathological study on palmar aponeurosis in Dupuytren's disease

The authors examined the immunological and immunohistochemical alterations of palmar aponeurosis in Dupuytren's contracture. In the IgG-content no difference were found between the intact and diseased aponeurosis. The mean of IgA content was 2 fold, the IgM content 3 fold higher in Dupuytren's aponeurosis than in normal ones. The immunoglobulin containing cells localised around the Dupuytren's nodules and in fibrotic, but not nodular parts of aponeurosis. Extracellular immunoglobulin deposits were not found.