交联琼脂糖包膜活性炭与甲壳素包膜树脂对色氨酸的吸附作用及其意义

血浆F-Trp被认为是引起肝性脑病发生机制之一,清除血浆F-Trp可能对防治肝性脑病具有一定意义。本文在体外CAAC吸附色氨酸的测定结果中,发现静态吸附2小时后血浆F-Trp及T-Trp分别下降为原有值的11.33%及50.69;动态吸附2小时后血浆F-Trp及T-Trp为原有值的3.94%及27.39%。CAAC对色氨酸水溶液的吸附能力则更优于血浆。吸附剂甲壳素包膜树脂的吸附能力则显然低于CAAC。 本文资料说明CAAC能有效地清除血浆F-Trp,并为开展CAAC血液灌流治疗肝性脑病提供了一定的理论依据。

The Significance of Tryptophanadsorption with Cross-Linked Agarose Coated Activated Charcoal and Chitin Resin

The high level of free trypto-phan F-Trp) in plasma hasbeen considered as one of thefactors in the pathogenesis ofhepato-encephalopathy (HE). Reduc-tion of F-Trp level to normal valuein the plasma may be significant inpreventing the occurrence of HE. Inthis paper, our results revealed thatafter 2hr static adsorption with Con-jugated Agarose-coated ActivatedCharcoal (CAAC) by the in vitromethod F-Trp and T-Trp levels inthe plasma decreased to 11.33% and50. 69% respectively, while using re-circulatory method they decreased to3.94 and 27.3%. Adsorption capacityof CAAC in aqueous solution of Trpwas even greater than that in theplasma. On the contrary, chitinDAC-coated resin adsorbed Trp in alesser degree. It is concluded thatCAAC is an effective adsorbent ineliminating plasma F-Trp, providinga theoretical basis for the use ofCAAC hemoperfusion in the treat-ment of HE.