139对双生子红细胞钠、钾离子的遗传度分析

利用遗传流行病学方法调查了天津市南开区139对双胞胎,其中单卵双生(MZ)74对,双卵双生(DZ)65对。并用几种不同的遗传度估计方法分析了红细胞Na⁺、K⁺的共同基因和共同环境因素对血压的影响。结果表明遗传因素、共同环境因素及双胞胎各自的环境因素对血压影响近似的是RBC Na⁺,h²=0.32,C²=0.35,u²=0.33。环境因素为主要原因的是RBC K⁺,C²=0.97。

An Analysis of Heritability for Intra-erythrocytic Na+, K+ in 139 Twins

By means of the twin model contributions of shared genes and shared environments for red blood cells Na+ and K+ were analysed by genetic and epidemiologic methods. Determination of zygosity was mainly based on examination of red blood cells system, including ABO blood group, MN blood group, P blood group, Rh blood group and secretor status of saliva, such that the probability a dizygotic pair being identical for all of these indices was less than 0.05. 139 pairs of twin in Nan Kai district Tianjin were investigated containing 74 pairs of monozygotic twins (MZ) and 65 pairs of dizygotic twins(DZ). Several methods of estimating genetic heritability (h2) were used, such as the three methods proposed by Vogel, the Holzinger's method. Levine's method based on model of variance analysis and path analysis. The degrees of compatibility of various h2 were also analysed. The contributions of shared genes, shared environments and twin's own special environments were similar for RBC Na+, h2 = 0.32, C2 = 0.35, u2 = 0.33. The contributions of shared environments were the main cause for RBC K+, C2 = 0.97.