吸烟对健康人血清HDL-C等7项指标水平影响的对比观察

经对生活和工作环境相似的40~69岁健康男性工人吸烟组697人和不吸烟组841人的对比观察,说明吸烟对健康人血清脂蛋白组分胆固醇水平有明显影响。吸烟组HDL-C、HDL₂-C、HDL₃-C、HDL₂-C/HDL₃-C明显低于不吸烟组,LDL-C、VLDL-C、LDL-C/HDL-C明显高于不吸烟组,且与吸烟量、时间、习惯呈剂量反应关系。吸烟是降低HDL-C、HDL₂-C、HDL₃-C、HDL₂-C/HDL₃-C和升高LDL-C、VLDL-C、LDL-C/HDL-C的危险因素。与不吸烟组相比,吸烟降低HDL-C等4项指标水平和升高LDL-C等3项指标水平的RR分别为1.09~5.77和2.37~3.59。被动吸烟者HDL-C等7项指标水平与轻度吸烟者相似,说明被动吸烟对血清脂蛋白组分胆固醇有明显影响。

Influence of Smoking on Cholesterol Concentrations in Serum Lipo-protein of Healthy Subjects

Sixty hundred and nineteen-seven smokers and 841 non-smokers among healthy male workers of 40-60 years of age were comparatively observed. Their housing environment and working conditions were similar. The results showed that smoking had remarkable influence on the cholesterol concentration in the serum lipo-protein of healthy subjects. The levels of HDL-C HDL2-C, HDL3-C and HDL2-C/HDL3-C of the smoking group were obviously lower than those of the non-smoking group, while the levels of LDL-C, VLDL-C and LDL-C/HDL-C of the smoking group were obviously higher than those of the non-smoking group. Moreover, these indices were significantly associated with the smoking amount, smoking duration, depth of inhalation. Smoking was an important dangerous factor for lowering levels of HDL-C, HDL2-C, HDL 3-C, HDL2-C/HDL3-C and raising levels of LDL-C, VLDL-C, LDL-C/HDL-C. The relative risk (RR) of the two factors were estimated to be 1.09-5.77 and 2.37-3.57 respectively. The levels of the 7 indices such as HDL-C of passive smokers were identical with those of light smokers. This showed that passive smoking also had marked influence on cholesterol concentrations in serum lipoprotein.