急性病毒性肝炎的病例对照研究与分型转归研究

对两所医院162例急性病毒性肝炎患者进行了血清学分型和流行病学研究,并对发病的一些危险因素按成组和配对方法进行了病例对照研究。结果甲肝为37.0%,乙肝为40.7%,非甲非乙型肝炎为19.8%。经单因素和多因素Logistic回归分析,甲肝发病主要与肝炎接触史(OR=10.56)和不洁饮食史(OR=4.25)有关;乙肝与肝炎接触史(OR=4.30)和家庭成员既往肝炎史(OR=5.66)有关;非甲非乙型肝炎与肝炎接触史(OR=3.82)、输血史(OR=16.67)和既往肝炎史(OR=6.56)有关。甲肝、乙肝和非甲非乙型肝炎的转慢率分别为0%、12.1%和16.7%。

Risk Factor for Acute Viral Hepatitis: A Case-Control Study

One hundred and sixty-two patients with acute viral hepatitis in two hospitals were studied between January and December, 1988. The risk factors, epidemiologic features and prognosis of those patients were investigated by case-control and follow-up study. Among the 162 patients, 37.0% were hepatitis A, 40.7% were hepatitis B, and 19.8% were non-A, non-B hepatitis; there were 4 cases of mixed infection and 3 cases of fulminant hepatitis not included in the study. By simple case-control and logistic regression analysis, the patients of hepatitis A more often had history of personal contact with hepatitis cases (OR = 10.56) and of ingesting some contaminated foods (OR = 4.25); hepatitis B more often had history of personal contact with hepatitis cases in their families or elsewhere (OR = 5.66; OR = 4.30 respectively); and hepatitis NANB more often had history of previous clinical hepatitis episode (OR = 6.56), of personal contact with cases of hepatitis (OR = 3.82) and of receiving a blood transfusion (OR = 16.67). Among hepatitis A, B and NANB cases, sequelae of chronic hepatitis after acute phase were found in 0%, 12.1% and 16.7% of cases, respectively.