| 国产血源性乙肝疫苗的远期效果评价 |
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| 引用本文： | 徐慧文,李东升,徐经武,王学良,门伯媛,郑全庆,刘蓬勃,宋全江,高海燕,庄贵华,王文娟,唐晓红,王科,陶明. 国产血源性乙肝疫苗的远期效果评价[J]. 中华流行病学杂志, 1992, 13(6): 362-365 |
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| 作者姓名： | 徐慧文 李东升 徐经武 王学良 门伯媛 郑全庆 刘蓬勃 宋全江 高海燕 庄贵华 王文娟 唐晓红 王科 陶明 |
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| 作者单位： | 西安医科大学流行病学教研室 710061 |
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| 摘 要： | 1986年4月至1990年5月用随机、双盲和有安慰剂对照的严格实验设计,在西安市郊区对265名5~9岁儿童进行国产血源性乙肝疫苗远期效果评价。疫苗组抗体峰值在T12,随后则下降。抗-HBs阳性率下降缓慢,抗-HBs几何均值下降急骤,但与安慰剂组相比均有显著差别。抗-HBs峰值高低及应答时间早晚与随后抗体持续时间长短呈正相关关系。四年观察结果显示疫苗对HBV感染的保护率为80%,如针对HBsAg而言,保护率为100%。
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| 关 键 词： | 乙型肝炎 疫苗 保护效价 |
| 收稿时间： | 1990-08-20 |
Evaluation of Long-term Efficacy on Plasma-derived Hepatitis B Vaccine |
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| Xu Huiwen. Evaluation of Long-term Efficacy on Plasma-derived Hepatitis B Vaccine[J]. Chinese Journal of Epidemiology, 1992, 13(6): 362-365 |
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| Authors: | Xu Huiwen |
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| Affiliation: | Department of Epidemiology, Xian Medical University. |
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| Abstract: | From April 1986 to May 1990, 265 pupils aged 5 to 9 years in Xian suburbs were studied to evaluate long-term efficacy of plasma-derived hepatitis B vaccine made in China. Anti-HBs titers in vaccine group reached the highest at twelfth month after the first injection and decreased afterwards. The positive rate of anti-HBs decreased slow, but geometric mean titers of anti-HBs fell sharply. Compared with placebo group, the differences were all significant. The peak anti-HBs titers and the response time positively correlated with the persistence of anti-HBs. 4 years observation showed that protection rate of hepatitis B vaccine against HBV infection was 80%. Protection rate was 100% if HBsAg was only considered. |
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| Keywords: | Hepatitis B vaccine Protection rate Anti-HBs |
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