| 大鼠移植慢性排斥组织中CD40和CD40L表达研究 |
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| 引用本文： | 周广臣,许纯孝,张怀强,关广骤,蒋小刚. 大鼠移植慢性排斥组织中CD40和CD40L表达研究[J]. 中国免疫学杂志, 2003, 19(1): 49-53 |
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| 作者姓名： | 周广臣 许纯孝 张怀强 关广骤 蒋小刚 |
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| 作者单位： | 1. 南京军区南京总医院解放军肾脏病研究所,南京,210002
2. 山东医科大学第二附属医院泌尿外科,济南,250000 |
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| 基金项目： | 山东省医药卫生科研项目 ( 1999A2 1) |
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| 摘 要： | 目的：观察大鼠移植肾慢性排斥肾组织中CD40／40L的原位表达特点。以期阐明CD40／CD40L共刺激通路在移植肾脏慢性排斥反应中的作用。方法：共分3个实验组：即同种异体移植不用药对照组、用品系移植组、同种异体移植CSA治疗组。用SP免疫组织化学方法对移植肾脏组织CD40／CD40L表达进行观察，并结合肾间质中浸润的炎性细胞CD3^ 和CD68^ 细胞数进行分析。结果：慢性排斥肾组织中CD40／CD40L表达分布不同，间质淋巴细胞以表达CD40为主，CD40L表达肾实质细胞表达为主。慢性排斥移植肾组织间质CD40^ 细胞数与CD3^ 、CD68^ 细胞数密切相关；CD40L^ 细胞数与CD3^ 细胞数呈正相关，与CD68^ 细胞数无相关性.结论：CD40／CD40L共刺激通路可能在移植肾慢性排斥的发生、发展过程中起重要作用。
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| 关 键 词： | 肾移植 慢性排斥反应 共刺激分子 |
| 文章编号： | 1000-484X(2003)01-0049-05 |
The expression of CD40/CD40L during chronic rejection of renal allograft in rats |
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| ZHOU Guang Chen,XU Chun Xiao,ZHANG Huai Qiang et al Research Institute of Nephrology,Jinlin Hospital,Nanjing University School of Medcine,Nanjing ,China. The expression of CD40/CD40L during chronic rejection of renal allograft in rats[J]. Chinese Journal of Immunology, 2003, 19(1): 49-53 |
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| Authors: | ZHOU Guang Chen XU Chun Xiao ZHANG Huai Qiang et al Research Institute of Nephrology Jinlin Hospital Nanjing University School of Medcine Nanjing China |
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| Affiliation: | ZHOU Guang Chen,XU Chun Xiao,ZHANG Huai Qiang et al Research Institute of Nephrology,Jinlin Hospital,Nanjing University School of Medcine,Nanjing 210002,China |
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| Abstract: | Objective:To study the characteristic of CD40 and CD40L expression during chronic rejection(CR) of renal allograft in rats and to investigate the possible pathogenic role of CD40/CD40L in CR allograft rejection Methods:Three groups of rats were included The expression of CD40/CD40L in the renal tissue was analyzed by immunochemistry of SP method The data was interpreted in the light of infiltrating CD3 and CD68 in the intersitium Results:There was different distribution of CD40 and CD40L in rat CR allograft rejection The striking CD40 staining of graft cellular inflitrates was observed in renal allografts with CR, CD40L expression predominantly presented in renal parenchyma of kidney allografts CD40 + and CD40L + cells in grafts of CR were significantly higher than those in the isograft group Furthermore,CD40 + infiltrates of renal allografts with CR had a positive correlation with CD3 +,CD68 + cells in the intersitium of grafts with CR CD40L + infiltrates also had a positive correlation with CD3 + infiltrates and had no correlation with CD68 + infiltrates of grafts with CR Conclusion:CD40/CD40L costimulatory molecules might play an important role in the pathogenesis of chronic renal allograft rejection |
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| Keywords: | Kidney transplantation Chronic rejection Costimulatory molecule |
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