| 异基因外周血造血干细胞移植治疗急性再生障碍性贫血--一例报告附文献复习 |
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| 引用本文： | 赵晓武,符粤文,彭晓景,陈蕾,董秀娟,侯天德,谷景棉. 异基因外周血造血干细胞移植治疗急性再生障碍性贫血--一例报告附文献复习[J]. 中华血液学杂志, 2001, 22(10): 536-538 |
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| 作者姓名： | 赵晓武 符粤文 彭晓景 陈蕾 董秀娟 侯天德 谷景棉 |
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| 作者单位： | 郑州市第三人民医院、郑州骨髓移植中心 |
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| 摘 要： | 目的探索异基因外周血造血干细胞移植治疗急性再生障碍性贫血(再障)的疗效及其长期造血重建.方法1例急性再障患者,30岁,供者为其胞弟,HLA配型完全相合.动员方案G-CSF250?μg/d×6d.预处理方案环磷酰胺(CTX)50mg·kg-1·d-1×4d,抗胸腺细胞球蛋白(ATG)20mg·kg-1·
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| 关 键 词： | 急性再生障碍性贫血 异基因外周血 造血干细胞移植 治疗 病例报告 |
| 修稿时间： | 2001-03-20 |
Treatment of acute aplastic anemia with allogeneic peripheral blood stem cell transplantation: a case report and literature review |
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| ZHAO Xiaowu,FU Yuewen,PENG Xiaojing,et al.. Treatment of acute aplastic anemia with allogeneic peripheral blood stem cell transplantation: a case report and literature review[J]. Chinese Journal of Hematology, 2001, 22(10): 536-538 |
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| Authors: | ZHAO Xiaowu FU Yuewen PENG Xiaojing et al. |
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| Affiliation: | Third People's Hospital of Zhengzhou, Zhengzhou 450000, China. |
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| Abstract: | OBJECTIVE: To report a patients with acute aplastic anemia(AAA) successfully treated with allogeneic peripheral blood stem cell transplantation(allo-PBSCT). METHODS: A 30 years old patient with AA received allo-PBSCT from a HLA-compatible sibling donor. PBSCs mobilization regimen was G-GSF 250 micrograms/d x 6. The conditioning regimen included (CTX 50 mg.kg-1.d-1) x 4 and (ATG 10 kg-1.d-01) x 2. 8.97 x 10(8) nucleated cells/kg, 9.20 x 10(6) CD34+ cells/kg, 11.20 x 10(5) CFU-GM/kg were transplanted. RESULTS: Hematopoietic reconstitution obtained on day 18 after allo-PBSCT. Monitoring of engraftment with three microsatellite markers showed mixed chimerism on day 18 and complete chimerism after day 25. No acute or chronic graft versus host disease (GVHD) occurred. In the follow-up duration of 240 days, the blood and bone marrow pictures were normal and the living status was good. CONCLUSION: Allo-PBSCT was an effective therapy in the treatment of acute aplastic anemia. |
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| Keywords: | Hematopoietic stem cell transplantation Anemia aplastic |
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