Characterization of tumor-infiltrating mononuclear cells in renal cell cancer: quantitative analysis by immunoperoxidase staining |
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| Authors: | Y Tomita T Nishiyama M Fujiwara S Sato |
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| Affiliation: | Department of Immunology, Niigata University, School of Medicine, Japan. |
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| Abstract: | In order to determine whether tumor-infiltrating mononuclear cells (TIM) of renal cell cancer (RCC) is suitable for adoptive immunotherapy, their number and characteristics were examined immunohistologically. TIM consisted of T cells and a smaller number of macrophages. Among T cells, CD8-positive cells were the dominant population which was reported to be more potent for the lysis of tumor cells. The number of T cells was variable: in 5 tumors no T cells were observed and in an other 5 the number of T cells were less than 2 x 10(6) cells/cm3. These results suggest that the TIM of RCC might be favorable for adoptive immunotherapy but TIM could not be available in some cases because of their small number. |
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