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Synthesis and antiviral activity of novelc-methyl branched cyclopropyl nucleosides
Authors:Eun?Yee?Kwak,Joon?Hee?Hong,Youngja?Park,Bo?Gil?Choi  author-information"  >  author-information__contact u-icon-before"  >  mailto:bgchoi@chonnam.ac.kr"   title="  bgchoi@chonnam.ac.kr"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author
Affiliation:College of Pharmacy, Chonnam National University, Kwangju 500-757, Korea.
Abstract:A series of novel cyclopropyl nucleosides was synthesized using the highly stereoselective Simmons-Smith reaction starting from 1,2:5,6-di-O-isopropylidene-D-mannitol. The structural assignments of these nucleosides were determined by NMR studies and X-ray crystallography. All the synthesized nucleosides were assayed against several viruses.
Keywords:Cyclopropyl nucleoside  Antiviral agent  Simmons-Smith cyclopropanation
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