| 盐酸左氧氟沙星缓释片体外释放研究 |
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| 引用本文： | 夏学军,刘玉玲,任怡. 盐酸左氧氟沙星缓释片体外释放研究[J]. 中国药学杂志, 2001, 36(5): 314-316 |
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| 作者姓名： | 夏学军 刘玉玲 任怡 |
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| 作者单位： | 中国医学科学院-中国协和医科大学药物研究所, |
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| 摘 要： | 目的制备盐酸左氧氟沙星缓释片，并对其体外释放进行研究。方法通过测定盐酸左氧氟沙星释放度，进行释放机制及影响因素研究。结果盐酸左氧氟沙星缓释片体外释放曲线符合Higuchi方程。释放介质、转篮转速对药物释放有明显影响。结论制备的盐酸左氧氟沙星缓释片具有明显缓释作用。
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| 关 键 词： | 盐酸左氧氟沙星 缓释片 释放度 释药动力学 |
| 文章编号： | 1001-2494(2001)05-0314-03 |
| 收稿时间： | 1999-11-03; |
| 修稿时间： | 1999-11-03 |
Study on the release of levofloxacin hydrochloride sustained-release tablets in vitro |
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| XIA Xue jun,LIU Yu ling,REN Yi. Study on the release of levofloxacin hydrochloride sustained-release tablets in vitro[J]. Chinese Pharmaceutical Journal, 2001, 36(5): 314-316 |
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| Authors: | XIA Xue jun LIU Yu ling REN Yi |
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| Affiliation: | Institute of Materia Medical,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100050,China |
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| Abstract: | OBJECTIVE To prepare levofloxacin hydrochloride sustained release tablets and evaluate drug dissolution in vitro .METHODS To study the mechanism and factors influencing drug release by determining dissolution rate.RESULT The release profile of levofloxacin hydrochloride from the tablets followed Higuchi kinetics.Drug release was influenced by the dissolution medium used and the speed of basket rotation.CONCLUSION The prepared sustained release tablets showed a obviously sustained release effect. |
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| Keywords: | levofloxacin hydrochloride sustained release tablets dissolution rate release kinetics |
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