脑出血患者血浆及脑血肿引流物ET、MDA、SOD、LPO对照研究

目的研究内皮素(ET)、丙二醛(MDA)、超氧化物歧化酶(SOD)、脂质过氧化物(LPO)脑出血患者含量改变的临床意义。方法分析脑出血患者血浆及脑血肿引流物ET、MDA、SOD、LPO含量改变。结果血浆和脑血肿引流物ET、MDA、LPO明显增高 ,其中脑血肿引流物增高更为显著。而血浆和脑血肿引流物SOD均明显降低 ,以脑血肿引流物降低更明显。结论脑出血时血管收缩因子增加 ,而舒张因子减少 ,同时脑内自由基产生增多 ,而清除自由基能力下降 ,这可能是脑出血时比较重要的病理机制

Contrast study between plasma and brain hamatoma drain of the endothelin, malondialdehyde,superoxide dismutase,lipid peroxidation in hypertensive cerebral hemorrhage patients

Objective To investigate the relationship between the plasma and the brain hamatoma drain of the endothelin(ET), malondialdehyde(MDA), superoxide dismutase(SOD), lipid peroxidation(LPO) in hypertensive cerebral hemorrhage patients. Methods To analyse the change of ET, MDA, SOD and LPO in the patients of the plasma and the brain hamatoma drain. Results Found to risen ET, MDA, LPO in the plasma and the hamatoma, even more marked enhancement in the hamatoma. But, SOD is markedly reduced, especially in the brain hamatoma drain. Conclusions The angiotensin increased and the vasodilator reduced in the patients with cerebral hemorrhage. The increased free radical and the lower ability of eliminating free radical may be more important pathogenic mechanism in hypertension cerebral hemorrhage.