Short report: treatment of gastric ulcer with lansoprazole or ranitidine: a multicentre clinical trial |
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| Authors: | P. MICHEL,M. LEMAIRE,R. COLIN,G. BOMMELAER&dagger ,J. C. RAMBAUD&Dagger ,J. L. DUPAS&dagger &dagger ,M. A. BIGARD¶ ,J. C. VERWAERD¶ ¶ |
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| Affiliation: | Hôpital Charles Nicolle, Rouen.;Laboratoires Houde France, Paris La Défense.;Hotel Dieu, Clermont-Ferrand.;Hôpital Saint-Lazare, Paris.;Hôpital Nord, Amiens.;CHU Brabois, Vandoeuvre les Nancy.;Hôpital de la Côte de Nacre, Caen, France. |
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| Abstract: | We studied the effectiveness of lansoprazole and ranitidine in promoting gastric ulcer healing in a multicentre double-blind trial, by comparing the proportion of healed ulcers after 4 and 8 weeks of treatment. One hundred and fifty-eight patients were randomly given either ranitidine (150 mg each morning and at bedtime) or lansoprazole (30 mg each morning and placebo at bedtime). One hundred and twenty-eight patients completed the trial (62 taking lansoprazole, 66 taking ranitidine). Fifty-one (80%) of those treated with lansoprazole and forty-two (62%) of those treated with ranitidine had healed ulcers at 4 weeks (P < 0.05). Sixty-one (98%) patients who received lansoprazole and 57 (86%) who received ranitidine had healed ulcers at 8 weeks (P < 0.05). The observed differences were not significant in the intention-to-treat analysis. No serious adverse event was reported with lansoprazole. |
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