| 小檗碱预防性治疗糖尿病肾病的研究进展 |
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| 引用本文： | 张雅晨, 孙建国. 小檗碱预防性治疗糖尿病肾病的研究进展[J]. 药学进展, 2023, 47(3): 217-226. DOI: 10.20053/j.issn1001-5094.2023.03.006 |
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| 作者姓名： | 张雅晨 孙建国 |
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| 作者单位： | 1.中国药科大学药物代谢动力学重点实验室, 江苏 南京 210009 |
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| 摘 要： | 糖尿病肾病是糖尿病微血管并发症之一，其发病机制复杂，与糖脂代谢紊乱、炎症、氧化应激、自噬受损、肠道菌群失调等因素交叉关联，也是导致终末期肾病的主要原因。综述了糖尿病肾病的主要发病机制以及小檗碱预防性治疗糖尿病肾病的研究进展，旨在为糖尿病肾病治疗药物的研发提供参考。
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| 关 键 词： | 糖尿病肾病 小檗碱 发病机制 糖尿病并发症 |
| 收稿时间： | 2022-06-20 |
Research Progress of Berberine in Prophylactic Treatment of Diabetic Nephropathy |
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| ZHANG Yachen, SUN Jianguo. Research Progress of Berberine in Prophylactic Treatment of Diabetic Nephropathy[J]. Progress in Pharmaceutical Sciences, 2023, 47(3): 217-226. DOI: 10.20053/j.issn1001-5094.2023.03.006 |
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| Authors: | ZHANG Yachen SUN Jianguo |
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| Affiliation: | 1.Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Diabetic nephropathy is one of the microvascular complications of diabetes mellitus. Its pathogenesis is complex and crosslinked with factors including glucolipid metabolism disorders, inflammation, oxidative stress, impaired autophagy, and intestinal flora imbalance. It is also the main cause of end-stage renal disease. This article has reviewed the main pathogenesis of diabetic nephropathy and the research progress of berberine in the prophylactic treatment of diabetic nephropathy, aiming to provide references for the development of drugs for the treatment of diabetic nephropathy. |
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| Keywords: | diabetic nephropathy berberine pathogenesis diabetes complications |
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