Brain sites involved in fear memory reconsolidation and extinction of rodents |
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| Affiliation: | 1. Department of Drug Discovery and Development, 4306 Walker Building, Auburn University, AL 36849, United States;2. Department of Psychology, Thach Hall, Auburn University, AL 36849, United States;3. Department of Psychology, Pryale House, Oakland University, Rochester, MI 48309, United States;4. Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia;1. Department of Psychiatry, Uniformed Services University (USU), School of Medicine, Bethesda, MD 20814, United States;2. Center for the Study of Traumatic Stress (CSTS), Bethesda, MD 20814, United States;3. Program in Neuroscience, Uniformed Services University (USU), School of Medicine, Bethesda, MD 20814, United States;4. Translational Research Institute (TRI), Institute for Health and Biomedical Innovation (IHBI), Department of Psychology and Counselling, Queensland University of Technology (QUT), Brisbane, QLD, Australia;1. Laboratório de Neurobiologia da Memória, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;2. Laboratório de Psicobiologia e Neurocomputação, Biophysics Department, Biosciences Institute, Federal University of Rio Grande do Sul, 91.501-970 Porto Alegre, Brazil;3. Graduate Program in Neuroscience, Institute of Health Sciences, Federal University of Rio Grande do Sul, 90.046-900 Porto Alegre, Brazil;1. Institut National de la Santé et de la Recherche Médicale U862, Neurocenter Magendie, Physiopathologie de la Plasticité Neuronale, Bordeaux, France.;2. Universitaire de Bordeaux, Institut de Bio-imagerie de Bordeaux, Bordeaux, France.;3. Unite Mixte de Recherche Centre National de la Recherche Scientifique 5293, Institut des maladies Neurodégénératives, Bordeaux, France.;4. Centre Hospitalier Universitaire de Bordeaux, Service de NeuroImagerie Diagnostique et Thérapeutique, Bordeaux, France. |
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| Abstract: | Fear memory is a motivational system essential for organisms survival having a central role in organization of defensive behaviors to threat. In the last years there has been a growing interest on conditioned fear memory reconsolidation and extinction, two specific phases of memorization process, both induced by memory retrieval. Understanding the mechanisms underlying these two mnemonic processes may allow to work out therapeutic interventions for treatment of human fear and anxiety disorders, such as specific phobias and post-traumatic stress disorder. Based on the use of one-trial conditioning paradigms, which allow to follow the evolution of a mnemonic trace in its various phases, the present paper has attempted to reorganize the current literature relative to the rodents highlighting both the role of several brain structures in conditioned fear memory reconsolidation and extinction and the selective cellular processes involved. A crucial role seems to be play by medial prefrontal cortex, in particular by prelimbic and infralimbic cortices, and by distinct connections between them and the amygdala, hippocampus and entorhinal cortex. |
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| Keywords: | “One-trial” aversive conditioning Fear memory reconsolidation Fear memory extinction Local temporary reversible treatments Amygdala Hippocampus Infralimbic cortex Prelimbic cortex Entorhinal cortex |
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