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Diet,behavior and immunity across the lifespan

Institution:	1. School of Psychological Science, La Trobe University, Melbourne, VIC, Australia;2. School of Health Sciences and Health Innovations Research Institute (HIRi), RMIT University, Melbourne, VIC, Australia;3. The Scripps Research Institute, La Jolla, CA, USA;4. Centre for Neuroendocrinology, Gravida: National Centre for Growth and Development, Department of Anatomy, University of Otago, Dunedin, New Zealand;5. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;1. Cerrahpasa School of Medicine, Department of Pediatric Psychiatry, Istanbul, Turkey;2. Elaz?? Education and Research Hospital, Department of Neurology, Elaz??, Turkey;3. Cerrahpasa School of Medicine, Department of Pediatric Rheumatology, Istanbul, Turkey;4. Cerrahpasa School of Medicine, Department of Neurology, Istanbul, Turkey;1. Division of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA;2. Division of Substance Abuse, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY, USA;3. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA;4. Albert Einstein College of Medicine, Bronx, NY, USA;5. Department of Family and Social Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA;1. Department of Physiology and Cell Biology, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel;2. Department of Medical Neuroscience, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada;3. Clinical Research Center, Soroka University Medical Center, Beer-Sheva, Israel;4. Department of Ophthalmology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel;5. Ophthalmology and Visual Sciences, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada;6. Department of Industrial Engineering and Management, Ben-Gurion University of the Negev, Beer-Sheva, Israel;7. Department of Psychiatry, Soroka University Medical Center, Beer-Sheva, Israel;8. Division of Endocrinology and Metabolism, University of British Columbia, Vancouver, British Columbia, Canada;1. Beijing HuiLongGuan Hospital, Peking University, Beijing, China;2. Institute of Chinese Integrative Medicine, Beijing HuiLongGuan Hospital, Peking University, Beijing, China;3. Institute of Mental Health, Peking University, Beijing, China;4. Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA;5. Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA;1. Department of Biology and Ecology of Fishes, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Müggelseedamm 310, 12587 Berlin, Germany;2. Division of Integrative Fisheries Management, Department of Crop and Animal Sciences, Faculty of Life Sciences, Humboldt-Universität zu Berlin, Invalidenstrasse 42, 10115 Berlin, Germany;3. State Sportfisher Association of Lower Saxony, Bürgermeister-Stümpel-Weg 1, 30457 Hannover, Germany

Abstract:	It is increasingly appreciated that perinatal events can set an organism on a life-long trajectory for either health or disease, resilience or risk. One early life variable that has proven critical for optimal development is the nutritional environment in which the organism develops. Extensive research has documented the effects of both undernutrition and overnutrition, with strong links evident for an increased risk for obesity and metabolic disorders, as well as adverse mental health outcomes. Recent work has highlighted a critical role of the immune system, in linking diet with long term health and behavioral outcomes. The present review will summarize the recent literature regarding the interactions of diet, immunity, and behavior.

Keywords:	Diet Nutrition Immune Inflammation Microglia Cytokine IL-18 Obesity Calorie restriction Lipopolysaccharide ACTH"} {"#name":"keyword" "$":{"id":"kw0060"} "$$":[{"#name":"text" "_":"adrenocorticotropic hormone ARC"} {"#name":"keyword" "$":{"id":"kw0070"} "$$":[{"#name":"text" "_":"arcuate nucleus BDNF"} {"#name":"keyword" "$":{"id":"kw0080"} "$$":[{"#name":"text" "_":"brain derived neurotropic factor BMI"} {"#name":"keyword" "$":{"id":"kw0090"} "$$":[{"#name":"text" "_":"body mass index CR"} {"#name":"keyword" "$":{"id":"kw0100"} "$$":[{"#name":"text" "_":"calorie restriction CRH"} {"#name":"keyword" "$":{"id":"kw0110"} "$$":[{"#name":"text" "_":"corticotropin-releasing hormone GR"} {"#name":"keyword" "$":{"id":"kw0120"} "$$":[{"#name":"text" "_":"glucocorticoid receptor HPA axis"} {"#name":"keyword" "$":{"id":"kw0130"} "$$":[{"#name":"text" "_":"hypothalamic–pituitary–adrenal axis IF"} {"#name":"keyword" "$":{"id":"kw0140"} "$$":[{"#name":"text" "_":"intermittent fasting IκB"} {"#name":"keyword" "$":{"id":"kw0150"} "$$":[{"#name":"text" "_":"inhibitory factor κB IL"} {"#name":"keyword" "$":{"id":"kw0160"} "$$":[{"#name":"text" "_":"interleukin Iba1"} {"#name":"keyword" "$":{"id":"kw0170"} "$$":[{"#name":"text" "_":"ionized calcium-binding adapter molecule LPS"} {"#name":"keyword" "$":{"id":"kw0180"} "$$":[{"#name":"text" "_":"lipopolysaccharide NHP"} {"#name":"keyword" "$":{"id":"kw0190"} "$$":[{"#name":"text" "_":"non-human primate NFκB"} {"#name":"keyword" "$":{"id":"kw0200"} "$$":[{"#name":"text" "_":"nuclear factor κB PVN"} {"#name":"keyword" "$":{"id":"kw0210"} "$$":[{"#name":"text" "_":"paraventricular nucleus of the hypothalamus poly I:C"} {"#name":"keyword" "$":{"id":"kw0220"} "$$":[{"#name":"text" "_":"polyinosinic:polycytidylic acid POMC"} {"#name":"keyword" "$":{"id":"kw0230"} "$$":[{"#name":"text" "_":"pro-opiomelanocortin TLR"} {"#name":"keyword" "$":{"id":"kw0240"} "$$":[{"#name":"text" "_":"toll-like receptor WT"} {"#name":"keyword" "$":{"id":"kw0250"} "$$":[{"#name":"text" "_":"wild type
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