首页 | 本学科首页   官方微博 | 高级检索  
检索        


An involvement of SR-B1 mediated p38 MAPK signaling pathway in serum amyloid A-induced angiogenesis in rheumatoid arthritis
Institution:1. Department of Clinical Pharmacology, Medical University of Vienna, Austria;2. Department of Laboratory Medicine, Medical University of Vienna, Austria;3. Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Austria;1. Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China;2. Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
Abstract:Serum amyloid A (SAA) has been reported high expression in autoimmune diseases, such as rheumatoid arthritis (RA). However, detailed molecular mechanisms induced by SAA in the pathogenesis of RA are still unclear. Herein, we focused on the role of SAA–SR-B1 mediated p38 MAPK signaling pathway in the process of RA angiogenesis. Our results showed that both SAA and SR-B1 predominantly localized to vascular endothelial cells, lining and sublining layers in RA synovium. In a series of in vitro experiments with human umbilical vein endothelial cells (HUVECs), SAA induced the endothelial cells (ECs) proliferation, migration and tube formation. However, blockage of SR-B1 and p38 MAPK inhibited SAA-induced cells proliferation, migration and tube formation. In conclusion, our data showed a possible molecular mechanism for SAA–SR-B1 induced angiogenesis events via p38 MAPK signaling pathway.
Keywords:Serum amyloid A  Scavenger Receptor Class B Type 1  Rheumatoid arthritis  p38 MAPK  Angiogenesis  SAA"}  {"#name":"keyword"  "$":{"id":"kw0035"}  "$$":[{"#name":"text"  "_":"serum amyloid A  SR-B1"}  {"#name":"keyword"  "$":{"id":"kw0045"}  "$$":[{"#name":"text"  "_":"scavenger Receptor Class B Type 1  RA"}  {"#name":"keyword"  "$":{"id":"kw0055"}  "$$":[{"#name":"text"  "_":"rheumatoid arthritis  p38 MAPK"}  {"#name":"keyword"  "$":{"id":"kw0065"}  "$$":[{"#name":"text"  "_":"p38 mitogen-activated protein kinase  FPRL1"}  {"#name":"keyword"  "$":{"id":"kw0075"}  "$$":[{"#name":"text"  "_":"formyl peptide receptor-like 1  TLR2"}  {"#name":"keyword"  "$":{"id":"kw0085"}  "$$":[{"#name":"text"  "_":"toll like receptor 2
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号