Deep brain stimulation for psychiatric disorders: Are nucleus accumbens and medial forebrain bundle two branches of the same tree? |
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| Institution: | 1. Department of Biology, Georgia State University, 24 Peachtree Center Avenue NE, Atlanta, GA 30303, United States;2. Neuroscience Institute, Georgia State University, 24 Peachtree Center Avenue NE, Atlanta, GA 30303, United States;3. Center for Obesity Reversal, Georgia State University, 24 Peachtree Center Avenue NE, Atlanta, GA 30303, United States;1. Institut de Neurociències and Unitat de Fisiologia Animal (Facultat de Biociències), Universitat Autònoma de Barcelona, Bellaterra, Barcelona 08193, Spain;2. Red Temática de Investigación Cooperativa en Salud (RETICS-Trastornos Adictivos), Madrid, Spain;3. Institut de Neurociències and Unitat Psicobiologia (Facultat de Psicologia), Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain;1. Neurochemical Research Group, Dept. of Neurology, University of Luebeck, Luebeck, Germany;2. Graduate School for Computing in Medicine and Life Science, Luebeck, Germany;3. Institute for Signal Processing, University of Luebeck, Luebeck, Germany;4. Dept. of Neurosurgery, University of Luebeck, Luebeck, Germany;5. Dept. of Neurosurgery, University Medical Center, Freiburg, Germany;1. Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology (LCEN3), Ghent University, Department of Neurology, Institute for Neuroscience, Ghent, Belgium;2. Department of Psychiatry and Medical Psychology, Ghent University, Ghent, Belgium;3. Department of Psychiatry, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium |
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| Abstract: | Purpose of this commentary is to discuss the relation of the nucleus accumbens (NA) with the medial forebrain bundle (MFB) and compare them as deep brain stimulation (DBS) targets in psychiatric disorders. Could a “bundle” be a more effective target than a “nucleus”? Or, more correctly, could an important “modulator” be a more effective target than a highly significant “pleasure center”? The answer hides in the fact that NA is a key component of the MFB. Thus NA dysfunction is synonym to MFB dysfunction. The NA is a “hot-spot” in the neurocircuitry of psychiatric disorders and further experimental investigation is needed for the MFB as a target for neuromodulation in depression, as well as to optimize benefit of psychiatric patients from neuromodulation treatment efforts. Are the NA and MFB two branches of the same tree? They definitely could be, particularly if the “tree” is the brain's “motivation super-system”. |
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| Keywords: | Deep brain stimulation Depression Medial forebrain bundle Nucleus accumbens Psychiatric disorders |
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