The metabolic syndrome and 10-year cognitive and functional decline in very old men. A population-based study |
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| Affiliation: | 1. Department of Epidemiology, Surveillance and Promotion of Health, National Institute of Health, Rome, Italy;2. Department of Gerontology, Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, Sapienza University, Rome, Italy;1. Institute of Gerontology, School of Health and Welfare, Jönköping University, Sweden;2. Department of Psychology, Indiana University Southeast, USA;3. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;4. Department of Psychology, University of California, Riverside, USA;5. Department of Psychology, University of Southern California, Los Angeles, USA;1. Department of Family Medicine, Renai Branch, Taipei City Hospital, 10F, No. 10, Sec. 4, Ren-Ai Rd., Taipei City 106, Taiwan;2. Department of Orthopaedics, Shin Kong Wu Ho-Su Memorial Hospital, No. 95, Wen-Chang Rd., Taipei City 111, Taiwan;3. National Taiwan University School of Medicine, No.1, Sec.1, Ren-Ai Rd., Taipei City 100, Taiwan;4. School of Medicine, Fu-Jen Catholic University, No. 510, Zhong-Zheng Rd., Xin-Zhuang Dist., New Taipei City 242, Taiwan;5. Institute of Epidemiology and Preventive Medicine and Department of Public Health, College of Public Health, National Taiwan University, 5F, No. 17, Hsu-Chow Rd., Taipei City 100, Taiwan;1. Research Education and Epidemiology Center, Changhua Christian Hospital, No. 135, Nan-Hsiao Street, Changhua 500-06, Taiwan, ROC;2. Institute of Gerontology, National Cheng Kung University, No. 1, University Road, Tainan City 701, Taiwan, ROC;1. Healthy Aging Research Centre, Chang Gung University, Taiwan;2. Department of Industrial and Business Management, Chang Gung University, Taiwan;3. Laboratory for Epidemiology, Department of Health Care Management, College of Management, Chang Gung University, Taiwan;4. Department of Urology, Chang Gung Memorial Hospital, Taiwan;1. Department of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, Japan;2. NGK Insulators, Ltd., Aichi, Japan;3. Health Design Inc., Tokyo, Japan;4. Azbil Corporation, Tokyo, Japan;5. Department of Global Health, School of Health Sciences, University of the Ryukyus, Okinawa, Japan;1. Department of Musculoskeletal Rehabilitation, Poznan University of Physical Education, Poland;2. Department of Pulmonological and Rheumatological Rehabilitation, Poznan University of Physical Education, Poland |
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| Abstract: | ObjectivesTo describe longitudinal relationships of metabolic syndrome (MetS) to cognitive decline and functional disability in a sample of older non-institutionalized men.Methodsdata from 1991 to 2000 of the Italian cohorts of the Finland, Italy, the Netherlands, Elderly (FINE) study, were used. Global cognitive function and functional disability, defined as limitations in mobility, basic (ADLs) and instrumental activities of daily living (IADLs) were screened in 1991 and 2000. MetS was defined according to the NCEP ATP-III criteria.ResultsThe study sample consisted of 195 men, baseline age 76.1 ± 3.1 years. Baseline MetS was prospectively associated with greater 10-year cognitive and functional decline in ADLs and IADLs. After multiple adjustment including age, education, marital status, ApoE ε4 allele, cerebrovascular disease and initial cognitive and depressive status, MetS predicted cognitive decline (B = −1.684, 95%CI = −2.202 to −1.167, p < 0.001) and risk of IADLs (OR = 1.09, 95% CI = 1.01–1.20, p = 0.048) and ADLs disability (OR = 1.35, 95%CI = 1.12–1.62, p < 0.001). Interestingly, such associations were not attributable to individual altered components of MetS nor to their sum. Incident disability in ADLs and IADLs were not explained by parallel decline in cognitive function.ConclusionsMetS as an entity was associated with accelerated cognitive and functional decline in a population-based sample of very old men. |
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| Keywords: | Metabolic syndrome Cognitive decline Functional disability Incidence |
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