Changes in the cannabinoids receptors in rats following treatment with antidepressants |
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| Institution: | 1. Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Drug Addiction Pharmacology, 31-343 Kraków, 12 Smętna street, Poland;2. Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Pharmacology, Laboratory of Pharmacology and Brain Biostructure, 31-343 Kraków, 12 Smętna street, Poland;3. Department of Forensic Medicine, Faculty of Medicine, Jagiellonian University Medical College, Grzegórzecka 16 St., 31-531 Kraków, Poland;4. Max-Delbrück-Center for Molecular Medicine, Department of Cardiovascular Research, Molecular Biology of Peptide Hormones, Robert-Rössle-Str. 10, 13125 Berlin, Germany;5. Berlin Institute of Health (BIH), Anna-Louisa-Karsch-Straße 2, 10178 Berlin, Germany;6. Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany;7. DZHK (German Centre for Cardiovascular Research; Deutsches Zentrum für Herz-Kreislauf-Forschung), Partner Site Berlin, Hessische Strasse 3-4, 10115 Berlin, Germany;8. Institute for Biology, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany;9. Department of Neuroscience, Karolinska Institute, Retzius väg 8, 171 77 Stockholm, Sweden |
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| Abstract: | The endocannabinoid (eCB) system plays a significant role in the pathophysiology of depression. The potential participation of this system in the mechanism of action of antidepressants has been highlighted in recent years. The aim of this study was to investigate the expression of cannabinoid (CB) receptors using Western blot and CB1 receptor density using autoradiography after acute or chronic administration of antidepressant drugs imipramine (IMI, 15 mg/kg), escitalopram (ESC, 10 mg/kg) and tianeptine (TIA, 10 mg/kg)]. Antidepressants given chronically elevated CB1 receptor density in the cortical structures and hippocampal areas, while a decrease of CB1 receptor density was observed in the striatum after IMI and ESC treatment. The CB1 receptor expression decreases in the dorsal striatum after chronic administration of IMI and ESC or the receptor rise in the hippocampus after chronic ESC and TIA treatment were confirmed using Western blot analyses. An increase in the CB2 receptor expression was observed in the cortical structures and hippocampus after chronic administration of ESC and TIA, while a decrease in this expression was noted in the striatum and cerebellum after chronic IMI treatment. Our results provide clear evidence that the antidepressant exposures provoke some modulations within the eCB system through CB receptors. |
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| Keywords: | Antidepressant Depression Endocannabinoid system |
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