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Determinants of delayed childhood cancer care in low- and middle-income countries: A systematic review
Authors:Cesia Cotache-Condor  Vinootna Kantety  Andie Grimm  Jahsarah Williamson  Kelsey R Landrum  Kristin Schroeder  Catherine Staton  Esther Majaliwa  Shenglan Tang  Henry E. Rice  Emily R. Smith
Affiliation:1. Department of Public Health, Baylor University, Waco, Texas, USA;2. Birmingham's Institute for Cancer Outcomes and Survivorship, University of Alabama, Birmingham, Alabama, USA;3. Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA;4. Division of Pediatric Oncology, Department of Pediatrics, Duke University, Durham, North Carolina, USA;5. Duke Global Health Institute, Duke University, Durham, North Carolina, USA

Division of Emergency Medicine, Department of Surgery, Duke School of Medicine, Duke University, Durham, North Carolina, USA;6. Division of Pediatric Oncology, Kilimanjaro Christian Medical Centre, Moshi, Tanzania;7. Duke Global Health Institute, Duke University, Durham, North Carolina, USA;8. Duke Global Health Institute, Duke University, Durham, North Carolina, USA

Division of Pediatric Surgery, Department of Surgery, Duke School of Medicine, Duke University, Durham, North Carolina, USA

Abstract:Early access to care is essential to improve survival rates for childhood cancer. This study evaluates the determinants of delays in childhood cancer care in low- and middle-income countries (LMICs) through a systematic review of the literature. We proposed a novel Three-Delay framework specific to childhood cancer in LMICs by summarizing 43 determinants and 24 risk factors of delayed cancer care from 95 studies. Traditional medicine, household income, lack of transportation, rural population, parental education, and travel distance influenced most domains of our framework. Our novel framework can be used as a policy tool toward improving cancer care and outcomes for children in LMICs.
Keywords:cancer care  global health  health services research  pediatric oncology
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