Mg2+ Transporters in Digestive Cancers |
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| Authors: | Julie Auwercx Pierre Rybarczyk Philippe Kischel Isabelle Dhennin-Duthille Denis Chatelain Henri Sevestre Isabelle Van Seuningen Halima Ouadid-Ahidouch Nicolas Jonckheere Mathieu Gautier |
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| Institution: | 1.Université de Picardie Jules Verne, UFR des Sciences, UR-UPJV 4667, F-80000 Amiens, France; (J.A.); (P.R.); (P.K.); (I.D.-D.); (H.S.); (H.O.-A.);2.Service d’Anatomie et Cytologie Pathologique, CHU Amiens-Picardie, F-80000 Amiens, France;3.Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277—CANTHER—Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France; (I.V.S.); (N.J.) |
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| Abstract: | Despite magnesium (Mg2+) representing the second most abundant cation in the cell, its role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is regulated by Mg2+ transporters including Mitochondrial RNA Splicing Protein 2 (MRS2), Transient Receptor Potential Cation Channel Subfamily M, Member 6/7 (TRPM6/7), Magnesium Transporter 1 (MAGT1), Solute Carrier Family 41 Member 1 (SCL41A1), and Cyclin and CBS Domain Divalent Metal Cation Transport Mediator (CNNM) proteins. Recent data show that Mg2+ transporters may regulate several cancer cell hallmarks. In this review, we describe the expression of Mg2+ transporters in digestive cancers, the most common and deadliest malignancies worldwide. Moreover, Mg2+ transporters’ expression, correlation and impact on patient overall and disease-free survival is analyzed using Genotype Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets. Finally, we discuss the role of these Mg2+ transporters in the regulation of cancer cell fates and oncogenic signaling pathways. |
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| Keywords: | magnesium transporters digestive cancers TCGA overall survival |
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