Screening and surgical prophylaxis for hereditary cancer syndromes with high risk of endometrial and ovarian cancer |
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Authors: | Alexandra S. Bercow MD Eric L. Eisenhauer MD |
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Affiliation: | 1. Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;2. Division of Gynecologic Oncology, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts |
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Abstract: | In the era of advanced cancer genomics, our recognition of hereditary cancer mutations continues to increase. Two of these conditions, which carry an increased risk of female cancers including endometrial, ovarian, breast, are hereditary breast and ovarian cancer syndrome and Lynch syndrome. Risk-reducing surgery, such as mastectomy, salpingo-oophorectomy, and hysterectomy may decrease cancer risk for mutation carriers. Background, indications, techniques, and consequences of these surgical procedures are reviewed. |
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Keywords: | BRCA endometrial cancer hereditary cancer Lynch syndrome ovarian cancer |
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