“Per protocol” practice patterns for Children's Oncology Group trials within the radiation oncology community |
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| Authors: | Kevin X Liu Lubna Hammoudeh Daphne A Haas-Kogan Stephanie A Terezakis |
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| Institution: | 1. Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA;2. Department of Radiation Oncology and Molecular Radiation Sciences, University of Minnesota, Minneapolis, Minnesota, USA |
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| Abstract: | Little is known about the prevalence of pediatric radiation oncologists treating patients off study according to Children's Oncology Group (COG) trials before data are available regarding toxicity and efficacy of novel radiotherapy regimens. We conducted a 12-question survey of 358 pediatric radiation oncologists to characterize practice patterns regarding ongoing and completed COG protocols off study. With 130 responses (40.3%), the prevalence of providing treatment per protocol, but off study, before data are available in abstract or peer-reviewed form varied from 9.1% (for ACNS1422) to 88.1% (for AHOD1331). Future studies are needed to understand the effects of these practice patterns on outcomes. |
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| Keywords: | ependymoma Ewing sarcoma Hodgkin lymphoma medulloblastoma neuroblastoma rhabdomyosarcoma |
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