Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in Qatar |
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| Authors: | Hanaa Mousa Nazmul Islam Vijay Ganji Susu M Zughaier |
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| Institution: | 1.College of Medicine, QU Health, Qatar University, Doha P.O. Box 2731, Qatar;2.#2Biomedical and Pharmaceutical research Unit, QU Health, Qatar University, Doha P.O. Box 2731, Qatar;3.Public Health Department, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2731, Qatar;4.Human Nutrition Department, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2731, Qatar; |
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| Abstract: | Low serum 25-hydroxyvitamin D 25(OH)D] is linked to an altered lipid profile. Monocytes play an important role in inflammation and lipid metabolism. Recently, monocyte percentage to HDL-cholesterol ratio (MHR) has emerged as a novel marker of inflammation. We investigated the association between serum 25(OH)D concentrations and MHR and serum lipids in young healthy adults. Data from the Qatar Biobank were utilized to investigate the relation between serum 25(OH)D and inflammation and serum lipid concentrations in healthy Qatari adults using multivariate regression analysis. Prevalence of serum 25(OH)D concentrations <12 ng/mL (deficiency), 12–20 ng/mL (insufficiency), and ≥20 ng/mL (sufficiency) were 55.8%, 29.9%, and 14.3%, respectively. Serum 25(OH)D was significantly inversely associated with monocyte percentage, MHR, total cholesterol, LDL-cholesterol, and triacylglycerol in multivariable adjusted analysis. MHR could be a potential biomarker to predict cardiometabolic diseases among young healthy Qataris. |
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| Keywords: | vitamin D 25-hydroxyvitamin D HDL monocyte percentage MHR inflammation |
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