The carpal tunnel syndrome and amyloidosis. A clinical and histological study |
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Authors: | O W Bjerrum C Rygaard-Olsen B Dahlerup F B Bang J Haase E jantzen J Overgaard P C Sehested |
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Affiliation: | 1. Department of Neurosurgery, Odense University Hospital, Sondre Boulevard, 5000 Odense CDenmark;2. Institute of Pathology, University Hospital of Copenhagen, Blegdamsvej 9, 2100 CopenhagenDenmark;3. Department of Neurosurgery, University Hospital of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Denmark |
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Abstract: | Twenty-six non-randomized patients with carpal tunnel syndrome are presented. It is documented that three out of four patients may be diagnosed pre-operatively by five or more clinical parameters. All patients were screened for amyloidosis in biopsies from the carpal tunnel. One patient presented amyloid deposits in the transversal carpal ligament. The importance of macro- and microscopic findings in the carpal tunnel inclusive local amyloidosis for the pathogenesis of the carpal tunnel is discussed. It is concluded that provided systemic amyloidosis is not suspected, screening for amyloidosis may have diagnostic interest, however without therapeutic consequences and therefore unnecessary. |
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Keywords: | carpal tunnel syndrome amyloidosis |
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