European and American Subgroup C Isolates of Avian Metapneumovirus belong to Different Genetic Lineages |
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Authors: | D Toquin O Guionie V Jestin F Zwingelstein C Allee N Eterradossi |
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Institution: | French Agency for Food Safety (AFSSA), Avian and Rabbit Virology Immunology and parasitology Unit (VIPAC), BP53, 22440, Ploufragan, France. |
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Abstract: | The gene encoding the attachment glycoprotein (G) was sequenced in three French isolates of-subgroup C avian metapneumovirus (APV-C) from ducks. With 1771 nt, this gene proved as long as recently published for North-American APV-C isolates from turkeys. The nt sequences of the duck viruses shared 99% identity but proved only 75-83% identical with their North-American counterparts, viruses of both origins encoding 585 amino acid (aa)-long G proteins. Alignments revealed more homogeneity within the European and North-American groups (at least 98 and 79% aa identity, respectively) than between European and North-American viruses (at best 70% a identity), and confirmed the presence of an extracellular divergent domain (positions 302-484) in APV-C G. A phylogenetic analysis demonstrated that North-American and French isolates of APV-C belonged to significantly different genetic lineages, in agreement with the different geographical origin and host species of these viruses. |
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Keywords: | duck metapneumovirus subgroup C attachment G Glycoprotein genetic variation |
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