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Progressive multifocal leukoencephalopathy in a case of acquired immune deficiency syndrome |
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| Authors: | J D Speelman J ter Schegget G T Bots J Stam B Verbeeten |
| Affiliation: | 1. Department of Neurology, Academic Medical Centre, University of Amsterdam, the Netherlands;7. Laboratory of Medical Microbiology, University of Amsterdam, the Netherlands;71. Department of Neuroradiology, Academic Medical Centre, University of Amsterdam, the Netherlands;77. Department of Neuropathology, University Hospital, Leiden, the Netherlands |
| Abstract: | The case of a 40-year-old homosexual male with A.I.D.S. (Acquired Immune Deficiency Syndrome) and P.M.L. (Progressive Multifocal Leukoencephalopathy) is described. The importance of a brain biopsy for diagnostic procedures, especially in the case of a patient with A.I.D.S. is stressed. The diagnosis P.M.L. has been made by means of light- and electronic microscopical examination, and the presence of JCV-DNA in the brain tissue has been confirmed by dot hybridization. Various antiviral treatments did not show any effect on the course of the P.M.L. |
| Keywords: | Progressive multifocal leukoencephalopathy acquired immune deficiency syndrome dot hybridization |
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