牙周炎症对冠心病患者CRP水平影响的初探

目的通过横向研究初步探讨牙周炎症对冠心病患者CRP水平的影响。方法受检者共60人，包括冠心病＋牙周炎组、单纯牙周炎组和健康对照组，每组20人。检测超敏C反应蛋白（hs—CRP），牙周临床指标包括牙周探诊深度、附着丧失、出血指数、菌斑指数，并检测血脂水平（HDL、LDL、TG、CHO）和白细胞计数。采用ANOVA法分析以上指标在各组间的差别，Pearson法分析hs—CRP与牙周指标间的相关性。结果牙周炎＋冠心病组hs．CRP显著高于单纯牙周炎组和健康组（P〈0．05），单纯牙周炎组的hs—CRP水平又显著高于健康组（P〈0．05）。牙周炎＋冠心病组牙周指标均高于单纯牙周炎组和健康组。受检者的血清hs—CRP水平与牙周指数显著相关（P〈0．05）。结论牙周感染和炎症可能是牙周炎＋冠心病患者hs—CRP水平升高的原因之一。

Effect of periodontal inflammation on serum CRP levels in patients with coronary heart disease

Objective To investigate the effect of periodontal inflammation on serum-CRP levels in patients with coronary heart disease. Methods Sixty subjects were enrolled in this study, including 20 patients with coronary heart disease and chronic periedontitis （CHD ＋ CP）, 20 patients with chronic periodontitis （CP）, 20 healthy controls （H）. Clinical periodontal parameters including probing depth （ PD ） , attachment loss （AL） , bleeding index （ BI ） and plaque index （PLI） were examined. Hs-CRP, HDL, LDL, TG, CHO, and WBC count were tested. Differences in periodontal parameters,hs-CRP levels and lipid levels among the three groups were analyzed by ANOVA. Correlations of CRP with periodontal parameters were analyzed by Pearson correlation. Results Hs-CRP levels of CP ＋ CHD group were significantly higher than that of CP group and H group （ P 〈 0. 05 ）. Hs-CRP levels in group CP were higher than in group H. The average PD, AL, BI, PLI were elevated in group CP ＋ CHD than in group CP and group H （ P 〈 0. 05 ）. Hs-CRP levels were significantly correlated to PD, BI and PLI. Conclusion Periodontal infection and inflammation might be one of the reasons for the increased hs-CRP in patients with coronary heart disease and chronic periodontitis.