缺血预处理脑保护机制研究

脑缺血预处理即给予短暂亚致死量缺血可对随后的长时间致死性缺血损伤产生耐受。各国学者就其机制进行了广泛研究并发现这与受体激活和一系列信号转导有关,涉及阿片受体、一氧化氮、腺苷、丝裂原活化蛋白激酶等信号途径、N-甲基-D-天冬氨酸受体、生长因子、线粒体和核生存蛋白、Toll样受体等。但具体机制尚未完全阐明且还处于动物实验阶段,如何把实验结果应用于临床是今后将要解决的问题。

Mechanism Study of Neuroprotective Effect of Ischemic Preconditioning

Brain ischemic preconditioning is that transient ischemia in sublethal dose will result in tolerance to the following ischemia in lethal dose for long time. Wide studies about its mechanism have been carried out by scholars in many countrles,which showed that this maybe related to a series of signal transduction, such as opioid receptor, NO, adenosine, signal transduction pathways, NMDA receptor, growth factor, mitochondrial and nuclear survival proteins as well as toll-like receptor and so on. But the specific mechanism has not been elucidated,and the study about it is still in the stage of animal experiment. How to apply the experimental results into clinic is a suspending question in future.