EphB2在结肠癌组织中的表达及其与血管生成的关系

背量与目的:研究酪氨酸蛋白激酶受体EphB2在结肠癌组织中的表达,及其与肿瘤血管生成之间的关系,探讨EphB2在结肠癌发生发展中的作用及其相关机制.材料与方法:运用免疫组化法检测43例结肠癌和10例正常结肠组织中EphB2的表达及间质微血管密度(microvessel density,MVD).结果:EphB2在大多数结肠癌细胞质中表达,EphB2的表达和结肠癌的浸润深度以及远处转移呈负相关(P＜0.01),与结肠癌组织的分化程度呈正相关(P＜0.01).EphB2的表达与结肠癌的MVD呈正相关(r=0.54,P＜0.05).结论:EphB2对于肿瘤的生长可能起抑制作用,EphB2表达的减少可能促进了肿瘤的形成和演进.EphB2抑制肿瘤生长的机制可能与其影响肿瘤血管的生成相关.

Expression of EphB2 in Color Carcinoma and Its Relationship with Angiogenesis

BACKGROUND AND AIM: To detect the expression of receptor tyrosine kinase EphB2 as well as its relationship with angiogenesis in colon carcinoma,and explore the possible mechanism.MATERIALS AND METHODS: The expressions of EphB2 in 10 normal tissues and 43 colon carcinoma were detected by immunohistochemisty,and stromal microvessel density(MVD) was counted according to the results of CD34 detectedby immunohistochemisty.RESULTS:The majority of colon carcinomas expressed EphB2 in the cytoplasm.There was positive correlation between EphB2 expression in the cytoplasm and tumor differentiation,but negative correlation between EphB2 and tumor infiltration depth.Expression of EphB2 was positive correlation with MVD in immunoreation.CONCLUSION: EphB2 may play suppressive role in carcinogenesis and progression of colon carcinoma.EphB2 may achieve its tumor suppressor through regulation of tumor angiogenesis.