"Flare" Followed by Successful Tamoxifen Therapy in Two Cases of Advanced Breast Cancer |
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| Authors: | TANAKA MASAHIRO; ADACHI ISAMU; KIMURA SATOSHI; YAMAGUCHI KEN; KIKUCHI KIYOSHI; ABE KAORU |
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| Institution: | Endocrinology Division, National Cancer Center Research Institute Tokyo |
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| Abstract: | An antiestrogen, tamoxifen, is an effective drug in the treatmentof advanced breast cancer. The drug is generally very well toleratedand serious side effects such as the so-called "flare in thetumor" have rarely been observed. We have had two patients withadvanced breast cancer who showed the "flare" soon after theinitiation of tamoxifen therapy, and both patients finally achievedpartial response to tamoxifen. It is important not to misinterpretthe "flare" as progressive disease during tamoxifen therapy. |
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