| 寿尔智胶囊对老年性痴呆模型鼠海马神经元c-fos、[Ca2+]i的影响 |
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| 引用本文： | 冯方俊,涂晋文. 寿尔智胶囊对老年性痴呆模型鼠海马神经元c-fos、[Ca2+]i的影响[J]. 湖北中医药大学学报, 2002, 4(3): 16-18 |
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| 作者姓名： | 冯方俊 涂晋文 |
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| 作者单位： | 湖北中医学院430061 |
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| 基金项目： | 湖北省自然科学基金资助课题 .鄂科计 99J13 3 |
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| 摘 要： | 为深入探讨寿尔智胶囊治疗老年性痴呆的作用机理 ,我们尝试从老年性痴呆模型鼠海马神经元细胞凋亡与细胞内游离钙 ([Ｃａ2 + ]ｉ)、原癌基因ｃ ｆｏｓ等的变化关系进行探讨 ,研究结果如下。1 材料与方法1 1 动物及分组将完成老年性痴呆造模[1] 之昆明种小白鼠随机分为 :对照
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| 关 键 词： | 老年性痴呆 动物模型 细胞内游离钙 c－fos基因 寿尔智胶囊 |
| 文章编号： | 1008-987X(2002)03-0016-03 |
| 修稿时间： | 2002-04-14 |
Effects of Shouerzhi Capsule on Intracellular Free Ca2+and C-fos Genetic Expression of Senile Dementia Model Rat''s Hippocampus Neuron Cells |
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| Feng Fangjun Director:Tu Jinwen Hubei College of Traditional Ciinese Medicine,Wuhan. Effects of Shouerzhi Capsule on Intracellular Free Ca2+and C-fos Genetic Expression of Senile Dementia Model Rat''s Hippocampus Neuron Cells[J]. Journal of Hubei University of Chinese Medicine, 2002, 4(3): 16-18 |
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| Authors: | Feng Fangjun Director:Tu Jinwen Hubei College of Traditional Ciinese Medicine Wuhan |
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| Affiliation: | Feng Fangjun Director:Tu Jinwen Hubei College of Traditional Ciinese Medicine,Wuhan 430061 |
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| Abstract: | To define effects of Shouerzhi capsule on intracellular free Ca 2+ and c fos genetic expression of senile dementia model rat's hippocampus neuron cells. Methods:By means of immunochemistry to observe c fos genetic expression of senile dementia model and through Fura 2 fluorescent technology to measure free Ca 2+ of hippocampus neuron cells.Results: Shouerzhi capsule can reduce not only c fos genetic expression but also the content of intracellular free Ca 2+ of the senile dementia model rat's hippocampus neuron cells.Conclusion: Shouerzhi capsule can regulate apoptosis of hippocampus neuron cells through reducing c fos genetic expression and intracellular free Ca 2+ content and can prevent and cure senile dementia. |
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| Keywords: | Senile dementia Animal model Intracellular free Ca 2+ C fog gene Shouerzhi capsule |
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