不同方法服用他巴唑对Graves病患者血清CRP水平的影响

目的了解Graves病患者血清C反应蛋白(CRP)水平,观察他巴唑(MMI)对CRP的影响,探讨Graves病的发病机制及MMI的作用机制。方法选择Graves病患者106例和健康查体健康者40例,检测血清CRP水平进行比较;将Graves病患者随机分为2组,A、B两组。两组的年龄、性别均无差异,P均<0.05。所有患者在治疗前和治疗后每周检查游离T3(FT3)、游离T4(FT4)、促甲状腺激素(TSH)、CRP,同时检测、血常规、肝功能、血脂和血糖。结果Graves病患者血清CRP水平明显高于健康者,P<0.01;CRP与FT3、FT4、TSH及甲状腺大小均无相关性,P均>0.05;经治疗后两组的CRP均下降,在FT3、FT4下降到正常时下降最明显;FT3、FT4均下降到正常的时间和例数比较两组均无显著性差异,P均>0.05。结论:急性时相反应与Graves病的发病有明显关系,并且是相对独立的一个因素;MMI能降低Graves病患者的CRP水平,具有抗炎作用,此作用可能是抗甲状腺之后的继发作用,而与MMI的服用方法无关。

The Effects of Methimazole with Different Regimen On CRP Serum Level in Patients with Grvaves Disease

Objective To observe the serum level of CRP in patients with Graves disease and the effect of methimazole(MMI) on CRP;To investigate the pathology of Graves and the mechanism of MMI.Methods106 patients with Graves disease and 40 healthy people were selected and their CRP serum levels were tested.106 patients were divided randomly into group A and group B.There are no obvious difference in age and sex between two groups(P<0.05).Several indexes in each group was examed pre-therapy and post-therapy every week,which include the detection of FT3,FT4,TSH,CRP,blood routine test,blood lipid,liver function and blood glucose level.ResultsThe serum level of CRP in patients was significantly higher than that in healthy people(P<0.01);There were no relativities between CRP and FT3,FT4,TSH and size of thyriod gland,(P>0.05);The CRP levels were decreased in both of the groups after the treatment,which is most obvious especialy when FT3 and FT4 reached normal levels;There were no significant differences in number of cases and period of time that FT3 and FT4 from high to normal between two groups,(P>0.05).ConclusionAcute phase reaction has close relationship with genesis of graves disease,and is a relative independent factor related to the pathology of Graves disease;MMI can decrease the CRP level and has anti-inflammatory effect,which may be its secondary action besides antithyriod function and has nothing to do with the regimen of MMI release the inflammation in patients with Graves disease probably because of it′s function of antithyriod,and not the ways of taking it.