POSSUM Predicts Decreased Overall Survival in Curative Resection for Colorectal Cancer |
| |
Authors: | Rebecca P Brosens MD Joannes L Oomen MD Afina S Glas PhD Aart van Bochove PhD Miguel A Cuesta PhD Alexander F Engel PhD |
| |
Institution: | (1) Department of Surgery, Zaans Medical Centre, Zaandam, The Netherlands;(2) Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, Amsterdam, The Netherlands;(3) Department of Medical Oncology, Zaans Medical Centre, Zaandam, The Netherlands;(4) Department of Surgery, VU Medical Centre, Amsterdam, The Netherlands;(5) Department of Surgery, Zaans Medical Centre, Koningin Julianaplein 58, 1502 DV Zaandam, The Netherlands |
| |
Abstract: | Purpose Poor condition at operation determined by the physiologic POSSUM score is related to postoperative mortality and morbidity
of colorectal cancer surgery. This study was designed to analyze the relationship between condition of patients with colorectal
cancer at operation and long-term overall survival.
Methods A total of 542 patients survived a radical resection for Stages I, II, or III colorectal cancer. Physiologic POSSUM score
at surgery, exclusive of age, was calculated for all patients. Mean physiologic POSSUM score was used as cutoff point to determine
low-risk and high-risk group patients. A Cox proportional hazard analysis was performed to study the effect of low-risk and
high-risk group on overall survival and to identify independent risk factors.
Results Five-year overall survival was significantly higher in low-risk group patients than in high-risk group patients (low-risk
group 66.6 percent vs. high-risk group 48.5 percent; P < 0.001). Differences in overall survival also were found when patients in Stages I, II, and III were analyzed separately.
Risk factors for overall survival were advanced stage of disease, poor tumor differentiation, mucinous adenocarcinoma, older
than age 70 years, and poor condition of the patient at time of operation.
Conclusions Poor condition at operation, as determined by physiologic POSSUM score, is a risk indicator for long-term overall survival
in colorectal cancer patients.
Poster presentation at the meeting of the European Association of Coloproctology, Geneva, Switzerland, September 16 to 18,
2004.
Reprints are not available. |
| |
Keywords: | POSSUM Colorectal cancer Comorbidity Survival |
本文献已被 PubMed SpringerLink 等数据库收录! |
|