慢性阻塞性肺病患者的人体组成

目的应用生物电阻抗分析法,检测慢性阻塞性肺病(COPD)患者的人体组成的改变。方法选择符合COPD诊断标准的37例住院患者作为研究对象,其中男性27例,女性10例,平均年龄(66.7±9.9)岁。49名健康志愿者作为对照,其中男性28名,女性21名,平均年龄为(64.3±8.3)岁。用生物电阻抗法测定人体组成。结果COPD患者的体重较健康志愿者显著降低(P<0.05),其中去脂体质(FFM)降低更加显著(P<0.01),脂肪含量(Fat%)相对增加(P<0.01);总体水(TBW)和TBW/体重明显低于健康志愿者(P<0.05),而女性患者TBW/FFM高于健康志愿者(P<0.05);男性患者的基础代谢率较健康志愿者显著降低(P<0.05)。结论COPD患者存在不同程度的瘦体质消耗增加,脂肪含量相对增加,造成机体总体水含量减少,基础代谢率降低。

The Body Composition of the Patients with Chronic Obstructive Pulmonary Disease

Objective To measure the body composition of the patients with chronic obstructive pulmonary dis-ease(COPD)by bioelectrical impedance analysis. Methods Body composition was measured by bioelec-trical impedance analysis in37patients with COPD and49healthy subjects. Results The investigation showed that the body weights(BW)significantly declined in patients with COPD(P<0.05),FFM?creased much more(P<0.01),and the fat compartment was significantly expanded(P<0.01).Total body water(TBW)and TBW/BW of the patients with COPD were significantly lower than that of the healthy subjects(P<0.05),while TBW/FFM of the female patients with COPD were significantly higher than that of the healthy subjects(P<0.05).Basal metabolic rate of the male patients with COPD were significantly lower than that of the healthy subjects(P<0.05). Conclusions COPD results in a decline of body weight,depletion of fat free mass and total body water,lower basal metabolic rate,and an ex-pansion of the fat compartment.