| KAI1/CD82和E-cadherin在子宫内膜癌的表达 |
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| 引用本文： | 黄筱竑,章彤华,平金良,袁慧琴.KAI1/CD82和E-cadherin在子宫内膜癌的表达[J].肿瘤学杂志,2009,15(9). |
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| 作者姓名： | 黄筱竑 章彤华 平金良 袁慧琴 |
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| 作者单位： | 湖州市中心医院,浙江,湖州,313000 |
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| 摘 要： | 目的]研究KAI1/CD82与E-cadherin在子宫内膜癌组织中的表达及其与临床病理参数的关系。方法]采用免疫组织化学EnVision二步法检测76例子宫内膜癌,15例非典型增生子宫内膜和20例正常增生期子宫内膜组织中KAI1/CD82、E-cadherin的表达。结果]KAI1/CD82在正常增生期子宫内膜、非典型增生内膜、子宫内膜癌的阳性表达率分别为95%、93.3%和60.5%;E-cadherin在正常增生期子宫内膜、非典型增生内膜、子宫内膜癌的异常表达率分别为0、6.67%和55.26%。KAI1/CD82在子宫内膜癌的表达与组织学分级、肌层浸润程度呈负相关(P=0.000,P=0.01)。E-cadherin在子宫内膜癌的表达与组织学分级及组织学类型有关。KAI1/CD82与E-cadherin在子宫内膜癌中的表达呈显著性相关(P<0.01)。结论]KAI1/CD82表达下调和E-cadherin异常表达增高与子宫内膜癌的进展有关。
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| 关 键 词： | KAI1/CD82 E-cadherin 免疫组织化学 子宫内膜肿瘤 |
Expression of KAI1/CD82 and E-cadherin in Endometrial Carcinoma |
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| Institution: | HUANG Xiao-hong; ZHANG Tong-hua; PING Jin-liang; et al. (Huzhou City Centre Hospital of Zhejiang Province; Huzhou 313000; China); |
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| Abstract: | Purpose] To investigate expression of KAI1/CD82 and E-cadherin in endometrial carcinoma, and its correlation with clinicopathological features. Methods] Expression of KAI1/CD82 and E-cadherin in 76 cases with endometrial carcinoma, 15 cases with uterine atypical endometrial hyperplasia and 20 cases with normal proliferative phase endometrium were detected immunohistochemically. Results] The expression rate of KAI1/CD82 in normal proliferative phase endometrium, in atypical endometrial hyperplasia and in ... |
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| Keywords: | KAI1/CD82 E-cadherin |
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