多沙唑嗪对兔血脂和血管内膜增生的影响

目的：探讨多沙唑嗪对兔动脉球囊损伤后血管狭窄的影响及与血脂的关系。方法：23只新西兰兔随机分为3组，正常对照组用普通饲料喂养并不予任何处理。另两组用高脂饲料喂养并行腹主动脉球囊损伤术，多沙唑嗪组术后应用多沙唑嗪控释片4mg／d灌胃，术后4周处死兔，观察各组血脂以及血管损伤处内膜、中膜厚度、新生内膜面积、管腔面积。结果：高脂喂养造成兔血脂明显增高。手术开始时多沙唑嗪组和球囊损伤组两组血脂水平无差异，手术4周后多沙唑嗪组总胆固醇较球囊损伤组降低，而高密度脂蛋白较球囊损伤组增高。术后多沙唑嗪组与球囊损伤组血管损伤处相比血管内膜增生减轻，新生内膜面积减少，管腔面积增加。结论：多沙唑嗪可以抑制高脂喂养加球囊损伤后兔腹主动脉血管的狭窄，可以降低血脂、抑制动脉粥样硬化进展。

Influence of Doxazosin on Vascular Stenosis after Balloon Injure in Rabbit Arteries

Objective:To study the influence of doxazosin on vascular stenosis after balloon injured abdominal artery on the hyperlipidemic atherosclerotic model of rabbits.And to find its relationship with serum lipid.Methods:23 New Zealand rabbits were randomlly divided into 3 groups.Normal contral group(n=5) was fed with ordinary diet and without any administration.The other two groups were fed with 1% cholesterol diet,and their abdominal arteries were injured by dilated balloon.Meanwhile doxazosin group was fed with doxazosin controlled release tablet 4 mg/d.Blood lipid were measured and compared with each other at 4th weeks after operating.Intima thickness?Media thinkness?Neointima area?Lumen area were analyzed by Hias-1000 imagining analysis system.In 3 groups vascular stenosis were compared with each other after balloon injured.Results:The blood lipid in rabbit fed by high cholesterol diet were more higher.There were no differense in blood lipid at the begining of the test between doxazosin group and balloon injure group.After operation for 4 weeks,the total cholesterol in doxazosin group was lower,and HDL-C was higher compared with balloon injure group.The intima thinkness were inhibited,neointima area were inhibited too,Lumen area was increased.Conclusion:Doxazosin can inhibit vascular stenosis formed by using high cholesterol diet plus balloon injured method,and reduce serum lipid and inhibite atherosclerotic progress.