镀银医用聚丙烯网片植入体内的安全性评价

摘要背景：为解决疝修补网片的感染问题，课题组旨在从“降低疝补片的感染率”这一目标着手，将银与医用聚丙烯网片结合起来，使其具有良好的抗菌性能，不仅能降低疝修补网片的感染率，而且可进一步应用于可能污染和已经污染的伤口中，扩大无张力疝修补术的应用范围。目的：初步评测镀银医用聚丙烯网片植入动物体内的安全性。方法：参照国际标准(ISO 10993系列)和国家标准(GB/T 16886系列)所推荐的生物学和动物试验:将镀银聚丙烯网片植入兔子体内，在不同时段观察兔子体质量变化，死亡情况，炎症、血生化、肝肾功指标，肝组织病理切片，评价急性、亚急性、慢性毒性反应。结果与结论：镀银聚丙烯网片植入体内后短期内未见明显毒性反应及死亡情况；血常规炎性、血生化、肝肾功能指标及肝组织苏木精-伊红染色显示，镀银聚丙烯网片组与对照组无明显差异性(P > 0.05)，符合一般的炎症指标转化规律。说明镀银医用聚丙烯网片植入体内具有良好的安全性。 关键词：镀银；聚丙烯网片；安全性；体内实验；新西兰大白兔doi:10.3969/j.issn.1673-8225.2010.42.012

Security evaluation of argentation medical polypropylene mesh in vivo

AbstractBACKGROUND: To reduce the infection of hernia repair mesh, the research group combined silver with medical polypropylene (PP) mesh, to obtain good antibacterial properties, thus not only reducing infection rates of hernia repair mesh, and further applying to potential contaminated and contaminated wounds, widening the application range of tension-free hernia repair.OBJECTIVE: To evaluate the security of medical PP mesh implanted in animals.METHODS: According to the biological and animal experiments recommended by international standards (ISO 10993 series) and national standard (GB/T 16886 series): After the argentation PP mesh was implanted in rabbits, we observed rabbit body weight, death, inflammation, blood biochemistry, liver and kidney function indicators at different periods. Hepatic tissue pathological sections were evaluated for acute, subacute and chronic toxic reactions.RESULTS AND CONCLUSION: After the argentation PP mesh was implanted, the rabbits had no obvious toxic reactions or death. There was no significant difference between the experimental group and control group in blood inflammatory, blood biochemistry, liver and kidney function indicators and liver tissue hematoxylin-eosin staining (P > 0.05), the mesh meets the transformation rule of general inflammation indicators. Argentation medical PP mesh has a good safety in vivo.