Relation of intragastric pH with the response of gastrin and somatostatin secretion to electrical vagal stimulation]

The association of gastrin and somatostatin secretion with intragastric pH was investigated in the in vitro experimental system that provides concurrent isolated rat stomach perfusion and vagal stimulation. As a result, it was found that the gastric cavity must be neutral or alkaline for gastrin secretion to respond to electrical vagal stimulation. For somatostatin secretion to respond to the same stimulus the gastric cavity must be acidic. It was further suggested that gastrin secretion may be regulated by non-cholinergic neurons which are in turn regulated by non-nicotinic preganglionic fibers, while somatostatin secretion may be regulated by non-cholinergic excitatory neurons as well as by cholinergic inhibitory neurons which are regulated by nicotinic preganglionic fibers.