| 黄素单加氧酶3在药物代谢中的作用 |
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| 引用本文： | 郝大程,杨凌. 黄素单加氧酶3在药物代谢中的作用[J]. 中国药理学与毒理学杂志, 2008, 22(5): 391-395. DOI: 10.3867/j.issn.1000-3002.2008.05.011 |
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| 作者姓名： | 郝大程 杨凌 |
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| 作者单位： | 1. 中国科学院大连化学物理研究所药用资源开发研究组,辽宁,大连,116023;中国科学院研究生院,北京,100083
2. 中国科学院大连化学物理研究所药用资源开发研究组,辽宁,大连,116023 |
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| 基金项目： | 国家自然科学基金，中国科学院知识创新工程项目 |
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| 摘 要： | 黄素单加氧酶(FMO,E.C.1.14.13.8)是重要的Ⅰ相代谢酶,由于与细胞色素P450(CYP450,E.C.1.14.14.1)具有相同的单加氧药物和异物代谢功能,其重要性被明显低估。本文在与CYP450进行对比的基础上,重点对FMO3的功能、变异、调控及应用等方面的最新进展进行了综述,并提出了进行FMO研究的未来策略。
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| 关 键 词： | 黄素单加氧酶3 代谢 变异(遗传学) 多态性,单核苷酸 |
| 收稿时间： | 2007-09-25 |
Role of flavin-containing monooxygenase 3 in drug metabolism |
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| HAO Da-Cheng,YANG Ling. Role of flavin-containing monooxygenase 3 in drug metabolism[J]. Chinese Journal of Pharmacology and Toxicology, 2008, 22(5): 391-395. DOI: 10.3867/j.issn.1000-3002.2008.05.011 |
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| Authors: | HAO Da-Cheng YANG Ling |
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| Affiliation: | (1. Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023,China; 2. Graduate University, Chinese Academy of Sciences, Beijing 100083,China) |
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| Abstract: | Flavin-containing monooxygenases (FMO) represent the second most important human monooxygenase system, after cytochrome P450. However, its importance is underestimated. This review summarized the distinctive characteristics of FMO3, including its function, genetic variation, regulation，application, etc. The population differences of FMO3 were also reviewed. Based on the above progress, the future strategy of FMO study in drug development was suggested. |
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| Keywords: | flavin-containing monooxygenase 3；metobolism； variation (genetics)；polymorphism single nucleotide |
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