| 5-HTTLPR基因多态与双相障碍及其情感气质类型的关联研究 |
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| 引用本文： | 苑成梅,禹顺英,李则挚,黄佳,洪武,钱伊萍,方贻儒. 5-HTTLPR基因多态与双相障碍及其情感气质类型的关联研究[J]. 上海交通大学学报(医学版), 2011, 31(11): 1518-1522. DOI: 10.3969/j.issn.1674-8115.2011.11.003 |
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| 作者姓名： | 苑成梅 禹顺英 李则挚 黄佳 洪武 钱伊萍 方贻儒 |
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| 作者单位： | 1. 上海交通大学医学院附属精神卫生中心心境障碍科,上海,200030
2. 上海交通大学医学院附属精神卫生中心遗传室研究室,上海,200030 |
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| 基金项目： | 国家自然科学基金项目(30270494); 国家高技术研究发展计划(“八六三”计划)(2006AA02Z430); “十五”国家科技攻关项目(2004BA720A21-02); 上海市卫生局公共卫生优秀青年人才项目(08GWQ075);上海市卫生局青年科研项目(2007Y14); 上海交通大学医学院“重点学科建设”基金(沪交医科[2008]-6)~~ |
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| 摘 要： | 目的探讨5-羟色胺转运体基因启动子区域(5-HTTLPR)基因多态性与双相障碍的关联,分析其与双相障碍患者情感气质类型的相关性。方法采用病例—对照研究设计,共纳入305例双相障碍患者和272名正常对照。用情感气质评定量表(TEMPS-A)评估情感气质类型,运用χ2检验、T检验或非参数检验、方差分析等统计学方法评估5-HTTLPR基因多态与双相障碍及其情感气质类型的相关性。结果在女性中,5-HTTLPR L/S多态与双相障碍相关(基因型χ2=6.769,P=0.034;等位基因χ2=6.028,P=0.014);5-HTTLPR L/S多态S等位基因与双相障碍患者的焦虑气质相关(t=8.248,P=0.005);5-HTTLPRrs25531 A/G多态LA等位基因与双相障碍患者的情感旺盛气质相关(Z=-2.205,P=0.027)。结论 5-HTTLPR基因多态性与女性双相障碍的患病情况相关,且能在一定程度上影响患者的某些情感气质。
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| 关 键 词： | 双相障碍 5-羟色胺转运体基因启动子区域 基因多态 情感气质 情感气质评定量表 |
Association of 5HTTLPR gene polymorphisms with bipolar disorder and affective temperaments |
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| YUAN Cheng-mei,YU Shun-ying,LI Ze-zhi,HUANG Jia,HONG Wu,QIAN Yi-ping,FANG Yi-ru. Association of 5HTTLPR gene polymorphisms with bipolar disorder and affective temperaments[J]. Journal of Shanghai Jiaotong University:Medical Science, 2011, 31(11): 1518-1522. DOI: 10.3969/j.issn.1674-8115.2011.11.003 |
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| Authors: | YUAN Cheng-mei YU Shun-ying LI Ze-zhi HUANG Jia HONG Wu QIAN Yi-ping FANG Yi-ru |
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| Affiliation: | YUAN Cheng-mei1,YU Shun-ying2,LI Ze-zhi1,HUANG Jia1,HONG Wu1,QIAN Yi-ping2,FANG Yi-ru1(1.Department of Mood Disorder,2.Department of Genetics,Shanghai Mental Health Center,Shanghai Jiaotong University School of Medicine,Shanghai 200030,China) |
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| Abstract: | Objective To explore the association of serotonin transporter gene-linked polymorphic region(5-HTTLPR) gene polymorphisms with bipolar disorder and affective temperaments.Methods Case-control design was adopted,and 305 patients with bipolar disorder and 272 normal controls were enrolled.Temperament Evaluation of Memphis,Pisa,Paris and San Diego-autoquestionnaire version(TEMPS-A) was employed to assess the affective temperaments.Chi-square test,T test,nonparametric test and ANOVA were used to explore the ass... |
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| Keywords: | bipolar disorder serotonin transporter gene-linked polymorphic region gene polymorphism affective temperament Temperament Evaluation of Memphis Pisa Paris and San Diego-autoquestionnaire version |
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