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| 抗性淀粉干预对糖尿病大鼠子代糖代谢的影响 | |
| 引用本文： | 沈丽,殷峻,周军. 抗性淀粉干预对糖尿病大鼠子代糖代谢的影响[J]. 上海交通大学学报(医学版), 2011, 31(12): 1707-1710. DOI: 10.3969/j.issn.1674-8115.2011.12.010 |
| 作者姓名： | 沈丽 殷峻 周军 |
| 作者单位： | 1. 上海交通大学附属第六人民医院临床营养科,上海,200233 2. 上海交通大学附属第六人民医院内分泌代谢科,上海,200233 3. 美国华盛顿退伍军人医学中心内分泌代谢实验室,Washington DC 20422 |
| 摘 要： | 目的探讨抗性淀粉干预糖尿病大鼠对其子代糖代谢的影响。方法 20只6周龄雌性2型糖尿病Goto-Kakizaki（GK）大鼠随机分为抗性淀粉组（GK-RS组,n=10）和等能量密度饲料对照组（GK-EC组,n=10）,以喂食等能量密度饲料的同龄Wistar雌鼠作为空白对照组（Wistar-EC组,n=10）,分组喂养直至分娩。在各组幼鼠中分别随机选取10只雄性幼鼠,常规饲料喂养至8周龄,每周3次记录体质量和摄食量,免疫组织化学法检测胰腺相对β细胞密度,ELISA法测定空腹血清胰岛素水平,口服葡萄糖耐量试验检测空腹血糖和餐后2 h血糖,以稳态模型的胰岛素抵抗指数（HOMA-IR）评估胰岛素敏感性。结果与GK-EC组比较,GK-RS组空腹血糖浓度显著降低（P〈0.05）,胰腺胰岛素含量明显升高（P〈0.05）,胰腺相对β细胞密度呈现增高趋势（P=0.07）。GK-EC与GK-RS组幼鼠的摄食量、体质量、HOMA-IR、餐后2 h血糖和血清空腹胰岛素水平比较,差异均无统计学意义（P〉0.05）。结论抗性淀粉干预糖尿病大鼠有益于改善其子代发生的糖代谢紊乱。 |
| 关 键 词： | 抗性淀粉 2型糖尿病 糖代谢 子代 |
Effects of dietary resistant starch on glucose metabolism in offsprings of diabetic rats |
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| SHEN Li,YIN Jun,ZHOU Jun. Effects of dietary resistant starch on glucose metabolism in offsprings of diabetic rats[J]. Journal of Shanghai Jiaotong University:Medical Science, 2011, 31(12): 1707-1710. DOI: 10.3969/j.issn.1674-8115.2011.12.010 | |
| Authors: | SHEN Li YIN Jun ZHOU Jun |
| Affiliation: | SHEN Li1,YIN Jun2,ZHOU Jun3(1.Department of Clinical Nutrition,the Sixth People's Hospital,Shanghai Jiaotong University,Shanghai200233,China,2.Department of Endocrinology and Metabolism,3.Laboratory of Endocrinology and Metabolism,Veterans Affairs Medical Center,Washington DC20422,USA) |
| Abstract: | Objective To investigate the effects of dietary resistant starch on glucose metabolism in offsprings of diabetic rats. MethodsTwenty female Goto-Kakizaki(GK) rats with type 2 diabetes aged 6 weeks were randomized into resistant starch diet group(GK-RS group,n=10) and energy control diet group(GK-EC group,n=10),and another 10 age-matched female Wistar rats fed with energy control diet were served as blank control group(Wistar-EC group).Ten male offsprings were randomly selected in each group,and were raised ... |
| Keywords: | resistant starch type 2 diabetes glucose metabolism offspring |
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