| 七氟醚预处理和后处理对婴幼儿体外循环心肌再灌注损伤的影响 |
| |
| 引用本文： | 孙瑛,朱明,张剑蔚,许文音,白洁,张马忠. 七氟醚预处理和后处理对婴幼儿体外循环心肌再灌注损伤的影响[J]. 上海交通大学学报(医学版), 2011, 31(9): 1316-1319. DOI: 10.3969/j.issn.1674-8115.2011.09.024 |
| |
| 作者姓名： | 孙瑛 朱明 张剑蔚 许文音 白洁 张马忠 |
| |
| 作者单位： | 上海交通大学医学院附属上海儿童医学中心麻醉科,上海,200127 |
| |
| 基金项目： | 上海市科委基金(08411960800)~~ |
| |
| 摘 要： | 目的探讨七氟醚预处理、后处理和预处理复合后处理对婴幼儿先天性心脏病手术中体外循环心肌再灌注损伤的影响。方法选择60例室间隔缺损行心内直视手术的患儿,随机分为对照组(整个麻醉过程中不应用吸入麻醉药)、预处理组(主动脉阻断前吸入1.5 MAC的七氟醚20 min)、后处理组(主动脉开放后吸入1.5 MAC的七氟醚20 min)和预处理+后处理组(主动脉阻断前后分别吸入1.5 MAC的七氟醚20 min),每组15例。记录和比较各组主动脉阻断时间、体外循环时间、手术时间和入心脏重症监护病房(CICU)后的呼吸机支持时间、CICU滞留时间以及住院时间;分别于麻醉诱导后(T0)、体外循环开始前(T1)、体外循环结束即刻(T2)和体外循环后1 h(T3)、6 h(T4)、12 h(T5)、24 h(T6),测定心肌损伤标志物血浆心肌肌钙蛋白Ⅰ(cTnⅠ)、肌红蛋白(Mb)和肌酸激酶同工酶(CK-MB)的质量浓度。结果各组间主动脉阻断时间、体外循环时间、手术时间、入CICU后的呼吸机支持时间、CICU滞留时间及住院时间比较,差异均无统计学意义(P>0.05)。各组T2～T6时点的血浆cTnⅠ、Mb和CK-MB质量浓度均显著...
|
| 关 键 词： | 体外循环 心肌再灌注损伤 心肌损伤标志物 七氟醚 预处理 后处理 婴幼儿 |
Effects of sevoflurane preconditioning and postconditioning on myocardial reperfusion injury under cardiopulmonary bypass in infants |
| |
| SUN Ying,ZHU Ming,ZHANG Jan-wei,XU Wen-yin,BAI Jie,ZHANG Ma-zhong. Effects of sevoflurane preconditioning and postconditioning on myocardial reperfusion injury under cardiopulmonary bypass in infants[J]. Journal of Shanghai Jiaotong University:Medical Science, 2011, 31(9): 1316-1319. DOI: 10.3969/j.issn.1674-8115.2011.09.024 |
| |
| Authors: | SUN Ying ZHU Ming ZHANG Jan-wei XU Wen-yin BAI Jie ZHANG Ma-zhong |
| |
| Affiliation: | SUN Ying,ZHU Ming,ZHANG Jan-wei,XU Wen-yin,BAI Jie,ZHANG Ma-zhong(Department of Anesthesiology,Shanghai Children Medical Center,Shanghai Jiaotong University School of Medicine,Shanghai 200127,China) |
| |
| Abstract: | Objective To investigate the effects of sevoflurane preconditioning and postconditioning on myocardial reperfusion injury under cardiopulmonary bypass in infants undergoing surgery for congenital heart disease.MethodsSixty children undergoing surgery for ventricular septal defect were randomly divided into control group(no inhalation anesthetics during the surgery),preconditioning group(inhalation of 1.5 MAC sevoflurane for 20 min before aortic cross clamping),postconditioning group(inhalation of 1.5 MAC se... |
| |
| Keywords: | cardiopulmonary bypass myocardial reperfusion injury myocardial injury marker sevoflurane preconditioning postconditioning infants |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
