| 灵芝对体外培养的大鼠主动脉平滑肌细胞的抗脂质过氧化作用 |
| |
| 引用本文： | 杜先华,王卫民,龚新荣,于龙顺.灵芝对体外培养的大鼠主动脉平滑肌细胞的抗脂质过氧化作用[J].中药新药与临床药理,2003,14(4):240-242. |
| |
| 作者姓名： | 杜先华 王卫民 龚新荣 于龙顺 |
| |
| 作者单位： | 1. 郧阳医学院药理教研室,湖北十堰,442000
2. 十堰市太和医院生命科学研究所,湖北,十堰,442000 |
| |
| 摘 要： | 目的 观察灵芝对培养的大鼠血管平滑肌细胞(VSMC)的抗脂质过氧化作用，探讨其在抗动脉粥样硬化(AS)中可能的作用机制。方法 分别用脂质过氧化物(LPO)、超氧化物歧化酶(SOD)检测试剂盒测定灵芝对VSMC培养液中LPO含量、SOD活性的影响。结果 灵芝能降低LPO含量，增强SOD活性，并有一定的量效关系。结论 灵芝对VSMC有抗脂质过氧化作用，其抗AS的作用机制可能与其对抗活性氧引发的脂质过氧化反应，增强体内抗氧化酶的活性有关。
|
| 关 键 词： | 灵芝／药理学 细胞培养 血管平滑肌细胞／药物作用 脂质过氧化物 超氧化物歧化酶 |
| 文章编号： | 1003-9783(2003)04-0240-03 |
| 修稿时间： | 2003年1月30日 |
Effect of Ganoderma Lucidum on Counteracting Lipid Peroxidation in Cultured Vascular Smooth Muscle Cells of Rats |
| |
| DU Xianhua,WANG Weimin,GONG Xinrong,YU Longshun.Effect of Ganoderma Lucidum on Counteracting Lipid Peroxidation in Cultured Vascular Smooth Muscle Cells of Rats[J].Traditional Chinese Drug Research & Clinical Pharmacology,2003,14(4):240-242. |
| |
| Authors: | DU Xianhua WANG Weimin GONG Xinrong YU Longshun |
| |
| Institution: | DU Xianhua1,WANG Weimin2,GONG Xinrong1,YU Longshun1 |
| |
| Abstract: | Objective To observe the effect of Ganoderma Lucidum (GL) on counteracting lipid peroxidation in cultured vascular smooth muscle cell(VSMC)and to explore its therapeutic mechanism for atherosclerosis. Methods The effects of GL on the content of lipid peroxide(LPO)and the activity of superoxide dismutase(SOD)in medium were studied . Results GL decreased LPO content and increased SOD activity in a dose-effect manner. Conclusion GL can counteract the lipid peroxidation in VSMC and its therapeutic mechanism for atherosclerosis may be related to the counteraction of lipid peroxidation and enhancement of endogenous antioxidase activity. |
| |
| Keywords: | Ganoderma Lucidum /pharmacology Cell culture Vascular smooth muscle cell/drug effects Lipid peroxide Superoxide dismutase |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
