Effects of alcohol and oxidative stress on liver pathology: the role of the mitochondrion |
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| Authors: | Cahill Alan Cunningham Carol C Adachi Masayuki Ishii Hiromasa Bailey Shannon M Fromenty Bernard Davies Adrian |
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| Affiliation: | Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. alan.cahill@mail.tju.edu |
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| Abstract: | This article represents the proceedings of a symposium at the 2001 Research Society on Alcoholism meeting in Montreal, Canada. The chairs were Alan Cahill and Carol C. Cunningham. The presentations were (1) Mitochondrial regulation of ethanol-induced hepatocyte apoptosis: possible involvement of proapoptotic Bcl-2 family protein Bax, by Masayuki Adachi and Hiromasa Ishii; (2) Effects of ethanol on mitochondrial reactive oxygen species production and oxidative protein modification, by Shannon M. Bailey; (3) Acute ethanol binges elicit widespread oxidative mitochondrial DNA damage and depletion: protective effects of antioxidants and inhibitors of ethanol metabolism, by Bernard Fromenty; and (4) Effects of chronic ethanol consumption upon hepatic mtDNA oxidative modification and depletion, by Alan Cahill and Adrian Davies. |
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| Keywords: | Mitochondria Ethanol Oxidative Stress Mitochondrial DNA Apoptosis |
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