| 气相色谱法测定盐酸洛哌丁胺中四种有机溶剂残留量 |
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| 引用本文： | 谷高强,周坤,黄淑萍,尹必喜.气相色谱法测定盐酸洛哌丁胺中四种有机溶剂残留量[J].中国医药,2009,4(1):528-529. |
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| 作者姓名： | 谷高强 周坤 黄淑萍 尹必喜 |
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| 作者单位： | 扬子江药业集团有限公司(泰州)新药研究院,江苏省泰州市,225321; |
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| 摘 要： | Objective To investigate a method of detecting four residual solvents in loperamide hydrochlo-fide. Methods The residual solvents in ioperamide hydrochloride included isopropanol, ethyl acetate, Methyl isobutyl ketone and methylbenzene. The concetrations were quantitatively detemined by headspace GC on J&W DB-624 column, FID detector. Nitrogen was used as the carry gas. The injector temperature was 200% and the detector temperature was 25℃, meanwhile the column temperature was programmed raised. Results The solvents were completely separated and the calibration CHives of each solvent showed good linear relationship within a certain range. Conclusion The method is sensitive, accurate and can be used for quality control.
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| 关 键 词： | 盐酸洛哌丁胺 有机溶剂残留量 气相色谱法 |
Capillary gas chromatographic determination of four residual solvents in loperamide hydrochioride |
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| Abstract: | |
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| Keywords: | Loperamide hydrochlorideResidual solventsGas chromatogram |
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