| 早期胃癌高迁移率族蛋白1表达与淋巴结微转移关系探讨 |
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| 引用本文： | 何伟玲,张常华,何裕隆,吴晖,宋武,杨东杰,蔡世荣,彭建军,詹文华.早期胃癌高迁移率族蛋白1表达与淋巴结微转移关系探讨[J].实用医学杂志,2011,27(7):1170-1172. |
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| 作者姓名： | 何伟玲 张常华 何裕隆 吴晖 宋武 杨东杰 蔡世荣 彭建军 詹文华 |
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| 作者单位： | 中山大学附属第一医院胃肠胰外科,广州市,510080 |
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| 基金项目： | 国家自然科学基金项目，广东省自然科学基金项目，广东省科技计划项目，教育部2009年大学生创新性实验计划项目 |
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| 摘 要： | 目的:研究早期胃癌组织中高迁移率族蛋白1(high mobility group box1,HMGB1)表达水平与淋巴结微转移的关系。方法:采用免疫组化方法检测早期胃癌组织中HMGB1的表达水平,并采用淋巴结组织HE染色和抗细胞角蛋白抗体CK20的检测判断淋巴结微转移,探讨HMGB1表达水平与淋巴结微转移的关系。结果:62例早期胃癌患者中总共有淋巴结1334个,11例患者62个淋巴结发现CK抗体阳性细胞,总淋巴结微转移率4.64(62/1334)。HMGB1在45.1%早期胃癌组织中表达,与肿瘤浸润深度呈正相关(P<0.05),随着分化程度降低而增强,有淋巴结转移组比无淋巴结微转移组中HMGB1表达明显增强。结论:胃癌组织HMGB1表达与胃癌分化程度、侵袭、转移和淋巴结微转移密切相关,HMGB1检测对判断预后和指导治疗有重要意义。
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| 关 键 词： | 胃肿瘤 高迁移率族蛋白1 细胞角蛋白 淋巴结微转移 |
Expression of HMGB1 in early gastric cancer and its correlation with lymph node micrometastasis |
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| HE Wei-ling,ZHANG Chang-hua,HE Yu-long,WU Hui,SONG Wu,YANG Dong-jie,PENG Jian-jun,ZHAN Wen-hua.Expression of HMGB1 in early gastric cancer and its correlation with lymph node micrometastasis[J].The Journal of Practical Medicine,2011,27(7):1170-1172. |
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| Authors: | HE Wei-ling ZHANG Chang-hua HE Yu-long WU Hui SONG Wu YANG Dong-jie PENG Jian-jun ZHAN Wen-hua |
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| Institution: | HE Wei-ling,ZHANG Chang-hua,HE Yu-long,WU Hui,SONG Wu,YANG Dong-jie,PENG Jian-jun,ZHAN Wen-hua. Department of gastrointestinal-pancreatic surgery,the First Affiliated Hospital of Sun Yat-sen University,Guang Zhou,510080. |
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| Abstract: | Objective To examine the expression of HMGB1 in early gastric cancer tissues and to evaluate its relationship with lymph node micrometastasis. Methods Expression of HMGB1 were detected by immunohistochemistray in 62 cases of early gastric cancer.Cytokeratin_20 gene was used to detect the micrometastasis of lymph node of the related cases by using IHC in addition to HE staining. Results In 62 early cancer patients with total 1334 lymph nodes,micrometastasis was found in 62 lymph nodes of 11 patients in the g... |
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| Keywords: | HMGB1 Stomach neoplasms/pathology Cytokeratin_20 Lymph node micrometastasis |
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