| 柳氮磺吡啶栓治疗实验性溃疡性结肠炎的药效学研究 |
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| 引用本文： | 许晋斌 许卫红. 柳氮磺吡啶栓治疗实验性溃疡性结肠炎的药效学研究[J]. 中国医药工业杂志, 1993, 24(9): 408-410 |
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| 作者姓名： | 许晋斌 许卫红 |
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| 作者单位： | 山西省药物研究所，山西省药物研究所，山西省药物研究所，山西职工医学院，山西省药物研究所，山西医学院，山西医学院 太原 030045，太原 030045，太原 030045，太原 030012，太原 030045，太原 030001，太原 030001 |
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| 摘 要： | 柳氮磺吡啶(SASP)栓经直肠给药治疗大鼠溃疡性结肠炎3周,见结肠粘膜出血、糜烂溃疡病变点数较阴性对照组明显减少。病理检查见粘膜的弥漫性炎症消失或减轻,充血、水肿以及肠腺和固有膜间的炎细胞浸润消失或明显减轻。坏死的上皮和腺体以及糜烂溃疡面已修复,肠腺的杯状细胞显著增加。疗效优于同剂量灌胃给药。
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| 关 键 词： | 柳氮磺吡啶 溃疡性 结肠炎 栓剂 |
PHARMACODYNAMIC INVESTIGATION OF SULFASALAZINE SUPPOSITORY IN EXPERIMENTAL ULCERATIVE COLITIS |
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| REN Jin-Bin,XU Wei-Hong,MA Wen-Yun,LIU Zhi-Rena,WANG Xiao-Hong,XU Da-Yib,GENG Yin-Fengb. PHARMACODYNAMIC INVESTIGATION OF SULFASALAZINE SUPPOSITORY IN EXPERIMENTAL ULCERATIVE COLITIS[J]. , 1993, 24(9): 408-410 |
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| Authors: | REN Jin-Bin XU Wei-Hong MA Wen-Yun LIU Zhi-Rena WANG Xiao-Hong XU Da-Yib GENG Yin-Fengb |
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| Affiliation: | REN Jin-Bin,XU Wei-Hong,MA Wen-Yun,LIU Zhi-Ren~a,WANG Xiao-Hong,XU Da-Yi~b,GENG Yin-Feng~b |
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| Abstract: | After sulfasalazine suppositories 2.0 or 1.0g/kg were administered to the rats with ulcerative colitis for 3 weeks, their macroscopic pathological changes decreased evidently in comparision with the control group. Histologically, it was seen that hyperemia, edema, inflammatory cell infiltration disappered or decreased evidently, tissue was repaired at the regions of erosion or ulcer, and goblet cells of gland increased in mucosa. The therapeutic effect of the suppository was superior to oral administration. |
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| Keywords: | sulfasalazine suppository ulcerative colitis |
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