| DA—201树脂与XAD—8树脂纯化甘草酸效果的HPLC考察 |
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| 引用本文： | 梁贵健 张福成. DA—201树脂与XAD—8树脂纯化甘草酸效果的HPLC考察[J]. 中国医药工业杂志, 1993, 24(8): 339-343 |
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| 作者姓名： | 梁贵健 张福成 |
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| 作者单位： | 中国人民解放军空军总医院 北京100036 |
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| 基金项目： | 国家自然科学基金资助项目 No.29205037 |
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| 摘 要： | 以 HPLC 为检测手段,比较了 DA-201(国产)与 Amberlite XAD-8(美国)大孔吸附树脂在纯化甘草酸方面的效果,结果表明 DA-201优于 Amberlite XAD-8。并采用 DA-201树脂,对从甘草浸膏制备甘草酸新工艺进行了优化研究。二次过柱洗脱物甘草酸含量可达75%左右,回收率在66%以上。新工艺的产品含量和收率较目前的生产方法高。
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| 关 键 词： | 甘草酸 高效液相色谱法 DA－201树脂 |
COMPARISON OF EFFICIENCY OF PURIFICATION OF GLYCYRRHIZIC ACID WITH DA-201 AND XAD-8 RESINS BY HPLC |
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| LIANG Gui-Jian ZHANG Fu-Cheng WEI Ning YAO De-Jia HUANG Jin. COMPARISON OF EFFICIENCY OF PURIFICATION OF GLYCYRRHIZIC ACID WITH DA-201 AND XAD-8 RESINS BY HPLC[J]. , 1993, 24(8): 339-343 |
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| Authors: | LIANG Gui-Jian ZHANG Fu-Cheng WEI Ning YAO De-Jia HUANG Jin |
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| Abstract: | By means of HPLC,comparison of the efficiency of purificationof glycyrrizic acid (GA)with domestic DA-201 resin,and Amberlite XAD-8resin was made.Parallel control tests showed that DA-201 resin was superior toXAD-8.The new process of GA purification from glycyrrhiza extract by DA-201resin was optimized.The purity and recovery of GA in the second eluate wereabout 75% and 66%,respectively.This method gave higher purity and recoveryof GA than conventional ones. |
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| Keywords: | glycyrrizic acid HPLC DA-201 resin Amberlite XAD-8 resin |
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